{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:14:15Z","timestamp":1792498455251,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the maternal and fetal outcomes of pregnancies in women with cystic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Single obstetric hospital and adult cystic fibrosis centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case\u2010note review of pregnant women with cystic fibrosis referred for antenatal care and delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal and fetal outcomes, mode of delivery, lung function and pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight pregnancies were studied in 41 women. There were two miscarriages, 44 singleton pregnancies and two sets of twins. All babies were liveborn and survived. The mean gestational age at delivery was 35.9\u00a0\u00b1\u00a03.3\u00a0weeks. There were no fetal abnormalities or terminations of pregnancy. The median birthweight centile was 31.9 (interquartile range 14.9\u201355.6). Twenty\u2010five (52.1%) of the women had pancreatic insufficiency and 17 (35.4%) required insulin. There was a positive correlation between booking predicted forced expiratory volume in 1\u00a0second (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub>) and gestational age at delivery (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Women with <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> \u226460% were more likely to deliver earlier and by caesarean section compared with women with <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> &gt;60% (35.0\u00a0\u00b1\u00a03.2\u00a0weeks versus 37.1\u00a0\u00b1\u00a03.0\u00a0weeks; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 and 75.0% versus 25.0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Three of the seven women with an <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> &lt;40% died within 18\u00a0months of delivery. Four of the eight women with <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content><jats:sub>1<\/jats:sub> 40\u201350% died between 2 and 8\u00a0years after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancy for women with cystic fibrosis is possible and results in favourable maternal and fetal outcomes, but the incidence of preterm delivery and caesarean section is increased. Women with pre\u2010existing poor lung function should be counselled antenatally to ensure that they understand the implications of their shortened life\u2010expectancy and parenthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12040","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T19:51:59Z","timestamp":1352749919000},"page":"354-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["The outcome of pregnancies in women with cystic fibrosis\u2014single centre experience 1998\u20132011"],"prefix":"10.1111","volume":"120","author":[{"given":"JG","family":"Thorpe\u2010Beeston","sequence":"first","affiliation":[{"name":"Department Obstetrics and Gynaecology Chelsea and Westminster NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Madge","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Brompton Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Gyi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Brompton Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hodson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Brompton Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bilton","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Brompton Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,12]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Cystic Fibrosis Trust[http:\/\/www.cftrust.or.uk\/aboutcf\/whatiscf\/]. 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