{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:49Z","timestamp":1793646949301,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King's College Hospital Trust","award":["2010-11"],"award-info":[{"award-number":["2010-11"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether pelvic organ prolapse (<jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content>) and sexual dysfunction are more severe in women with benign joint hypermobility syndrome (<jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content>) than in the normal population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ing's <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> Foundation Trust, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ondon, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ondon, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women diagnosed with <jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) at <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital. Control participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) recruited from <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ing's <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> Foundation Trust.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Objective assessment of <jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content> was undertaken using the Pelvic Organ Prolapse Quantification System (<jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>). Both groups were asked to complete the Prolapse quality of life (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) and pelvic organ prolapse\/urinary incontinence sexual (<jats:styled-content style=\"fixed-case\">PISQ<\/jats:styled-content>\u201012) questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Comparison of vaginal anatomy using <jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content> between the two groups. Comparison of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PISQ<\/jats:styled-content>\u201012 quality of life scores between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 120 women (60 in Study group, 60 in Control group) were recruited. All women in the study group were matched with healthy control women according to age, parity and ethnicity. There was a statistically significant difference between points <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>a, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>a, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>p, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>p and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in study and control groups showing that prolapse is objectively more severe in those with <jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content>. Significantly more women with <jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content> felt that <jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content> interfered with sex and defecation compared with the control group. The impact of prolapse symptoms on quality of life was statistically different in almost all nine <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A large number of women with <jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content> have prolapse symptoms, which significantly affect their quality of life. <jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content> is more severe in women with <jats:styled-content style=\"fixed-case\">BJHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12082","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T17:43:16Z","timestamp":1355506996000},"page":"187-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Prolapse and sexual function in women with benign joint hypermobility syndrome"],"prefix":"10.1111","volume":"120","author":[{"given":"H","family":"Mastoroudes","sequence":"first","affiliation":[{"name":"King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Giarenis","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cardozo","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Srikrishna","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vella","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Robinson","sequence":"additional","affiliation":[{"name":"University College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kazkaz","sequence":"additional","affiliation":[{"name":"University College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Grahame","sequence":"additional","affiliation":[{"name":"University College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.26.5.419"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1532-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.5.413"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00182-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.5.559"},{"key":"e_1_2_10_7_1","first-page":"239","article-title":"Joint hypermobility syndrome: inherited disorder of collagen synthesis","volume":"13","author":"Child AH","year":"1986","journal-title":"J Rheumatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-3633-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.4.382"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1518-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107583"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.10.602"},{"key":"e_1_2_10_13_1","unstructured":"Sliecker\u2010tenHMCP VierhoutM BloembergenH SchoenmakerGDistribution of pelvic organ prolapse in a general population: prevalence severity etiology and relation with function of pelvic floor muscles. 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