{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:34:43Z","timestamp":1773074083775,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of large loop excision of the transformation zone (<jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>) for cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>) on cervical morphology as assessed by three\u2010dimensional ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University Hospital in Dublin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> who underwent an <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All 106 participants had a three\u2010dimensional transvaginal ultrasound scan (3<jats:styled-content style=\"fixed-case\">DTVS<\/jats:styled-content>) performed immediately before and 6\u00a0months after <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>. The excised <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> specimen dimensions were also recorded. Blind analysis of the images was performed. The volume of the uterus and cervix was documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The relationship between the extirpated <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> dimensions and subsequent cervical and uterine biometry, as assessed by 3<jats:styled-content style=\"fixed-case\">DTVS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> induced a statistically significant reduction in both the length (mean, \u20130.46\u00a0cm; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and the volume (\u20136.12\u00a0cm<jats:sup>3<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) of the uterus, and in the volume of the cervix (\u20131.60\u00a0cm<jats:sup>3<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). The volume of the excised specimen had a significant impact on the reduction of the length of the uterus (\u03b2, \u20130.038; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.012), the volume of the uterus (\u03b2, \u20130.791; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.036) and the volume of the cervix (\u03b2, \u20130.121; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.046). The circumference of the excised specimen appeared to have a significant impact on the length (\u03b2, \u20130.016; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u20130.028 to \u20130.003; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.013) and volume (\u03b2, \u20130.413; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u20130.719 to \u20130.107; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.009) of the uterus 6\u00a0months after <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The volume of tissue removed at <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> is related to the subsequent cervical volume, as well as the uterine length and volume, 6\u00a0months after the procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12105","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T12:13:39Z","timestamp":1355228019000},"page":"472-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Image assessment of cervical dimensions after <scp>LLETZ<\/scp>: a prospective observational study"],"prefix":"10.1111","volume":"120","author":[{"given":"X","family":"Carcopino","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Assistance Publique des H\u00f4pitaux de Marseille (APHM) Marseille France"},{"name":"Aix\u2010Marseille Universit\u00e9 (AMU) University of Medicine Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JA","family":"Maycock","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Colposcopy Clinic The Adelaide and Meath Hospital Tallaght Dublin 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