{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:12:07Z","timestamp":1784657527462,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the outcome of pregnancies complicated by placental insufficiency and abnormal umbilical artery <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler prior to viability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Singleton pregnancies with fetal growth restriction and absence of end\u2010diastolic velocities (<jats:styled-content style=\"fixed-case\">AEDV<\/jats:styled-content>s) in the umbilical arteries prior to 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of singleton pregnancies with fetal growth restriction and <jats:styled-content style=\"fixed-case\">AEDV<\/jats:styled-content>s in the umbilical arteries prior to 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Fetal growth restriction and <jats:styled-content style=\"fixed-case\">AEDV<\/jats:styled-content>s in the umbilical arteries prior to 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 16 fetuses first seen at 20\u201323\u00a0weeks, only 12 survived and one of these developed cerebral palsy. Severe hypertensive disorders occurred in three mothers. In four women, the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler waveforms progressively improved and developed a normal pulsatility. These fetuses had a better outcome than those that had persistent alterations: they were delivered later (34 versus 28\u00a0weeks), had a larger birthweight (1598 versus 630\u00a0g) and developed fewer complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placental insufficiency with <jats:styled-content style=\"fixed-case\">AEDV<\/jats:styled-content> in the umbilical arteries prior to fetal viability is associated with a high probability of perinatal death and neonatal complications. However, progressive amelioration of Doppler indices occurs in a subset of women, and these fetuses have a much better outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12133","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T16:32:25Z","timestamp":1358267545000},"page":"754-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcome of severe placental insufficiency with abnormal umbilical artery <scp>D<\/scp>oppler prior to fetal viability"],"prefix":"10.1111","volume":"120","author":[{"given":"G","family":"Simonazzi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Curti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cattani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pilu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology St. Orsola Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16809-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1158"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1902"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(98)00131-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.06.002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4101"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181da213e"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.02.009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.133"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.055251"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2001.602.doc.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.041"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.12133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:36:18Z","timestamp":1697373378000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.12133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/1471-0528.12133"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.12133","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]},"assertion":[{"value":"2012-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}