{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:35:15Z","timestamp":1791315315363,"version":"4.3.1"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Several biomarkers for predicting intrauterine growth restriction (\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      ) have been proposed in recent years. However, the predictive performance of these biomarkers has not been systematically evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the predictive accuracy of novel biomarkers for\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      in women with singleton gestations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>Electronic databases, reference list checking and conference proceedings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>\n                      Observational studies that evaluated the accuracy of novel biomarkers proposed for predicting\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and analysis<\/jats:title>\n                    <jats:p>\n                      Data were extracted on characteristics, quality and predictive accuracy from each study to construct 2\u00a0\u00d7\u00a02 tables. Summary receiver operating characteristic curves, sensitivities, specificities and likelihood ratios (\n                      <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\n                      s) were generated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>\n                      A total of 53 studies, including 39\u00a0974 women and evaluating 37 novel biomarkers, fulfilled the inclusion criteria. Overall, the predictive accuracy of angiogenic factors for\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      was minimal (median pooled positive and negative\n                      <jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>\n                      s of 1.7, range 1.0\u201319.8; and 0.8, range 0.0\u20131.0, respectively). Two small case\u2013control studies reported high predictive values for placental growth factor and angiopoietin\u20102 only when\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      was defined as birthweight centile with clinical or pathological evidence of fetal growth restriction. Biomarkers related to endothelial function\/oxidative stress, placental protein\/hormone, and others such as serum levels of vitamin D, urinary albumin\u00a0:\u00a0creatinine ratio, thyroid function tests and metabolomic profile had low predictive accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      None of the novel biomarkers evaluated in this review are sufficiently accurate to recommend their use as predictors of\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      in routine clinical practice. However, the use of biomarkers in combination with biophysical parameters and maternal characteristics could be more useful and merits further research.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.12172","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T09:50:56Z","timestamp":1360576256000},"page":"681-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"120","author":[{"given":"A","family":"Conde\u2010Agudelo","sequence":"first","affiliation":[{"name":"Perinatology Research Branch Eunice Kennedy Shriver National Institute of Child Health and Human Development\/National Institutes of Health\/Department of Health and Human Services Bethesda MD and Detroit, MI 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