{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:26:06Z","timestamp":1754483166936},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Recent studies have identified specific symptoms of ovarian cancer at all stages, raising the hope of reducing diagnostic delays. We aimed to devise a scoring system for symptoms of ovarian cancer in primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of data from a case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Thirty\u2010nine general practices in Exeter, mid\u2010Devon and east Devon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Two hundred and twelve women with ovarian cancer and 1060 age\u2010, sex\u2010 and practice\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Conditional logistic regression was used to produce an additive scoring system and its receiver operator characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve. Several different cut\u2010offs were then tested using a simple costs model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each woman was assigned a score based on her symptoms in the year before diagnosis: we added a score for women aged \u226550\u00a0years, reflecting their increased incidence of ovarian cancer. The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve was 0.883 (95% confidence interval 0.853\u20130.912). The chosen cut\u2010off had a sensitivity of 72.6% and a specificity of 91.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This scoring system could potentially direct general practitioners to appropriate investigations for ovarian cancer on the basis of symptoms and save a substantial number of unnecessary ultrasound scans being requested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12200","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T10:12:05Z","timestamp":1364465525000},"page":"1016-1019","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ovarian cancer prediction: development of a scoring system for primary care"],"prefix":"10.1111","volume":"120","author":[{"given":"K","family":"Grewal","sequence":"first","affiliation":[{"name":"University Hospital Bristol Bristol Royal Infirmary Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Peninsula College of Medicine &amp; Dentistry Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Sharp","sequence":"additional","affiliation":[{"name":"Centre for Academic Primary Care School of Social and Community Medicine University of Bristol Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"P Walsh N Cooper Ovary M Quinn H Wood N Cooper S Rowan 2005 Macmillan Palgrave 193 201"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11090563"},{"key":"e_1_2_7_4_1","unstructured":"National Institute for Health and Clinical Excellence. Recognition and initial management of ovarian cancer. (Clinical guideline 122.)2011.www.nice.org.uk\/CG122."},{"key":"e_1_2_7_5_1","volume-title":"Guidance on direct access to diagnostic tests for cancer published","author":"Department of Health"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22371"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2998"},{"key":"e_1_2_7_8_1","volume-title":"Statistics\/Data Analysis. Stata\/IC 11 1 for Mac","author":"StataCorp","year":"2010"},{"key":"e_1_2_7_9_1","volume-title":"Ovarian Cancer\u2014UK incidence statistics","author":"Cancer Research UK"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d8009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01153.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-2-199407150-00009"},{"key":"e_1_2_7_13_1","volume-title":"Bowel Cancer Services: Costs and Benefits","author":"York Health Economics Consortium","year":"2007"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.12200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:24:42Z","timestamp":1697430282000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.12200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/1471-0528.12200"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.12200","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]},"assertion":[{"value":"2013-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}