{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:19:03Z","timestamp":1791584343338,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate salivary progesterone as a predictor of early preterm birth (<jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>) and compare it with transvaginal sonographic (<jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content>) cervical length in asymptomatic high\u2010risk women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Departments of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>bstetrics and <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ynaecology and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iochemistry at <jats:styled-content style=\"fixed-case\">UCMS<\/jats:styled-content> &amp; <jats:styled-content style=\"fixed-case\">GTBH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> D<\/jats:styled-content>elhi, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Ninety pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The progesterone concentration in saliva of asymptomatic pregnant women at high risk for preterm delivery was estimated by immunoassay, and cervical length was measured by <jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content>, at the first antenatal visit at 24\u201328\u00a0weeks of gestation, and then repeated 3\u20134\u00a0weeks later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Early <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content>, mean and critical cut\u2010off values of salivary progesterone, and a diagnostic value comparison of salivary progesterone with <jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> cervical length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean value of salivary progesterone was significantly lower in all women who delivered at &lt;37\u00a0weeks of gestation (<jats:italic>n<\/jats:italic>\u00a0=\u00a038), compared with the term group (<jats:italic>n<\/jats:italic>\u00a0=\u00a052; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Salivary progesterone decreased significantly from the first to the second visit, with the maximum decrease observed in women who delivered at &lt;34\u00a0weeks of gestation (29.6%, 95% CI 17.8\u201341.4%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.002). The single predictive critical cut\u2010off value for salivary progesterone was 2575\u00a0pg\/ml, below which more than 80% of women delivered prematurely before 34\u00a0weeks of gestation, with sensitivity, specificity, and positive and negative predictive values of 83% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 58.6\u201396.4%), 86% (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 75.9\u201393.1%), 60% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 38.6\u201378.8%) and 95% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 87.1\u201399.0%), respectively. The <jats:styled-content style=\"fixed-case\">TVS<\/jats:styled-content> cervical length decreased significantly (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) in the women who delivered prematurely.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low salivary progesterone concentration can be used for predicting early <jats:styled-content style=\"fixed-case\">PTB<\/jats:styled-content> in asymptomatic high\u2010risk women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12217","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T14:33:12Z","timestamp":1364913192000},"page":"1003-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Salivary progesterone as a biochemical marker to predict early preterm birth in asymptomatic high\u2010risk women"],"prefix":"10.1111","volume":"120","author":[{"given":"B","family":"Priya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Guleria","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NB","family":"Vaid","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BD","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RS","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Environmental Biochemistry and Molecular Biology Laboratory Department of Biochemistry University College of Medical Sciences &amp; Guru Teg Bahadur Hospital University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2004.04.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600965882"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067815"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000980206"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2003.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02293.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00422-0"},{"key":"e_1_2_7_9_1","first-page":"608","article-title":"Actions of placental and fetal adrenal steroid hormones in primate pregnancy","volume":"16","author":"Pepe GJ","year":"1995","journal-title":"Endocrine Rev"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.9.875"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/33176"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03801.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.12.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32716-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818b1ff6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000150560.24297.4f"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"Progesterone for prevention of preterm delivery. 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