{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:27:09Z","timestamp":1774531629338,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Objective<\/jats:title>To investigate the aggregation of obstetric anal sphincter injuries (OASIS<\/jats:styled-content>) in relatives.<\/jats:p><\/jats:sec>Design<\/jats:title>Population\u2010based cohort study.<\/jats:p><\/jats:sec>Setting<\/jats:title>The M<\/jats:styled-content>edical B<\/jats:styled-content>irth R<\/jats:styled-content>egistry of N<\/jats:styled-content>orway from 1967 to 2008.<\/jats:p><\/jats:sec>Population<\/jats:title>All singleton, vertex\u2010presenting infants weighing 500\u00a0g or more. Through linkage by national identification numbers, 393\u00a0856 mother\u2013daughter pairs, 264\u00a0675 mother\u2013son pairs, 134\u00a0889 mothers whose sisters later became mothers, 132\u00a0742 fathers whose brothers later became fathers, 131\u00a0702 mothers whose brothers later became fathers and 88\u00a0557 fathers whose sisters later became mothers were provided.<\/jats:p><\/jats:sec>Methods<\/jats:title>Comparison of women with and without a history of OASIS<\/jats:styled-content> in their relatives.<\/jats:p><\/jats:sec>Main outcome measure<\/jats:title>Relative risk of OASIS<\/jats:styled-content> after a previous OASIS<\/jats:styled-content> in the family.<\/jats:p><\/jats:sec>Results<\/jats:title>The risk of OASIS<\/jats:styled-content> was increased if the woman's mother or sister had OASIS<\/jats:styled-content> in a delivery (aRR<\/jats:styled-content> 1.9, 95% CI<\/jats:styled-content> 1.6\u20132.3; aRR<\/jats:styled-content> 1.7, 95% CI<\/jats:styled-content> 1.6\u20131.7, respectively). If OASIS<\/jats:styled-content> occurred in one brother's partner at delivery, the risk of OASIS<\/jats:styled-content> in the next brother's partner was modestly increased (aRR<\/jats:styled-content> 1.2, 95% CI 1.1\u20131.4). If OASIS<\/jats:styled-content> occurred in one sister at delivery, the risk of OASIS<\/jats:styled-content> in the brother's partner was also increased a little (aRR<\/jats:styled-content> 1.2, 95% CI<\/jats:styled-content> 1.1\u20131.4). However, there was no excess occurrence in sisters whose brothers' partners had previously had OASIS<\/jats:styled-content> (aRR<\/jats:styled-content> 1.1, 95% CI 0.9\u20131.3).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There appears to be increased familial aggregation of OASIS<\/jats:styled-content>. These risks are stronger through the maternal rather than the paternal line of transmission, suggesting a strong genetic role that shapes aggregation of OASIS<\/jats:styled-content> within families. These observations must be cautiously interpreted because of bias from unmeasured confounding factors may have impacted the findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12220","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T15:25:40Z","timestamp":1364311540000},"page":"831-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Familial risk of obstetric anal sphincter injuries: registry\u2010based cohort study"],"prefix":"10.1111","volume":"120","author":[{"given":"E","family":"Baghestan","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Obstetrics and Gynaecology Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LM","family":"Irgens","sequence":"additional","affiliation":[{"name":"Medical Birth Registry of Norway Norwegian Institute of Public Health University of Bergen Bergen Norway"},{"name":"Locus for Registry Based Epidemiology Department of Public Health and Primary Health Care University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PE","family":"B\u00f8rdahl","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Obstetrics and Gynaecology Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Obstetrics and Gynaecology Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.512073"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-007-0431-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01445.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-2243(88)80007-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.04.033"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e2f50b"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181eda77a"},{"key":"e_1_2_6_9_1","unstructured":"The Medical Birth Registry of Norway. 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