{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:49:43Z","timestamp":1792230583338,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is conflicting literature on the effect of maternal asthma on congenital malformations and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This review and meta\u2010analysis sought to determine if maternal asthma is associated with an increased risk of adverse neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We searched electronic databases for: (asthma or wheeze) and (pregnan* or perinat* or obstet*).<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Cohort studies published between 1975 and March 2012 reporting at least one perinatal outcome of interest (congenital malformations, neonatal complications, perinatal mortality).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>In all, 21 studies met inclusion criteria in pregnant women with and without asthma. Further analysis was conducted on 16 studies where asthmatic women were stratified by exacerbation history, corticosteroid use, bronchodilator use or asthma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Maternal asthma was associated with a significantly increased risk of congenital malformations (relative risk [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] 1.11, 95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.02\u20131.21, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a059.5%), cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.30, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.01\u20131.68, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a065.6%), neonatal death (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.49, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.11\u20132.00, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%), and neonatal hospitalisation (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.50, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.03\u20132.20, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a064.5%). There was no significant effect of asthma on major malformations (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.57\u20133.02, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a070.9%) or stillbirth (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.9\u20131.25, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a035%). Exacerbations and use of bronchodilators and inhaled corticosteroids were not associated with congenital malformation risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Authors\u2019 conclusions<\/jats:title><jats:p>Despite limitations related to the observational nature of the primary studies, this review demonstrates a small increased risk of neonatal complications among pregnant women with asthma. Further investigations into mechanisms and potential preventive interventions to improve infant outcomes are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12224","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T15:25:29Z","timestamp":1364311529000},"page":"812-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"120","author":[{"given":"VE","family":"Murphy","sequence":"first","affiliation":[{"name":"Centre for Asthma and Respiratory Diseases University of Newcastle and Hunter Medical Research Institute Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Wang","sequence":"additional","affiliation":[{"name":"Pneumology 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