{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:13Z","timestamp":1787013673953,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,8]]},"abstract":"\n Objective<\/jats:title>\n \n To develop and evaluate a questionnaire to assess the burden of vulval intraepithelial neoplasia (\n VIN<\/jats:styled-content>\n ) in women.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A questionnaire development study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n V<\/jats:styled-content>\n ulval\n D<\/jats:styled-content>\n isorders\n C<\/jats:styled-content>\n linic serving a regional population.\n <\/jats:p>\n <\/jats:sec>\n \n Sample<\/jats:title>\n \n Fifty\u2010eight women with a histological diagnosis of\n VIN<\/jats:styled-content>\n registered with the\n V<\/jats:styled-content>\n ulval\n D<\/jats:styled-content>\n isorders\n C<\/jats:styled-content>\n linic.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 37\u2010item questionnaire was developed through a comprehensive literature review, consultation with specialist clinicians and pretesting to assess the burden experienced by women. The questionnaire was assessed for validity and reliability against existing questionnaires used in related disease areas.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n Spearman correlations were calculated between items in the\n VIN<\/jats:styled-content>\n questionnaire with the scores of the Dermatology Life Quality Index (\n DLQI<\/jats:styled-content>\n ), Hospital Anxiety and Depression Scale (\n HADS<\/jats:styled-content>\n ), Sabbatsberg Sexual Self\u2010Rating Scale (\n SSRS<\/jats:styled-content>\n ) and the Process Outcome Specific Measure (\n POSM<\/jats:styled-content>\n ) to assess the new questionnaire's validity. Internal consistency was measured using Cronbach's alpha. Test\u2013retest reliability was calculated using quadratic weighted kappa.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n VIN<\/jats:styled-content>\n questionnaire had a high degree of internal consistency (Cronbach's alpha, 0.89). Test\u2013retest reliability was assessed, with most questions showing a quadratic weighted kappa value of 0.5 or above. Most questions showed a stronger correlation with the corrected total\n VIN<\/jats:styled-content>\n score than with\n HADS<\/jats:styled-content>\n anxiety and depression subscales and the\n SSRS<\/jats:styled-content>\n , indicating discriminant validity. Most questions correlated significantly with the\n DLQI<\/jats:styled-content>\n and\n POSM<\/jats:styled-content>\n scores, indicating convergent validity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Initial assessment of the\n VIN<\/jats:styled-content>\n questionnaire demonstrated that it is a valid and reliable measure of the burden of disease for women. The questionnaire could be used to compare new and existing treatments for\n VIN<\/jats:styled-content>\n or to assess or monitor the impact of care.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.12229","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T07:12:35Z","timestamp":1365577955000},"page":"1133-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The development and evaluation of a questionnaire to assess the impact of vulval intraepithelial neoplasia: a questionnaire study"],"prefix":"10.1111","volume":"120","author":[{"given":"J","family":"Lockhart","sequence":"first","affiliation":[{"name":"Dugald Baird Centre Aberdeen Maternity Hospital Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NM","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Applied Health Sciences Academic Primary Care University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ME","family":"Cruickshank","sequence":"additional","affiliation":[{"name":"Division of Medical and Dental Education McGillivray Academic Centre Aberdeen Maternity Hospital Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"23","article-title":"Pilot study of sexual function and quality of life after excision for vulvar intraepithelial neoplasia","volume":"52","author":"Likes WM","year":"2007","journal-title":"J Reprod Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.023"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2008.00291.x"},{"key":"e_1_2_6_5_1","unstructured":"CruickshankM McFaddenK.Report from VIN Qualitative Study. 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