{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:34:08Z","timestamp":1762659248794},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Women with hypertensive pregnancy disorders (<jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>) are at increased risk of developing hypertension and cardiovascular disease later in life; however, it is not known how cardiovascular risk develops throughout life. We evaluated the longitudinal trends in cardiovascular risk factors in women after hypertensive pregnancy disorders compared with women with normotensive pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and population<\/jats:title><jats:p>All women of the Doetinchem Cohort Study (1987\u201391), a population\u2010based cohort study, were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women were examined (questionnaires and physical examination) four times at 5\u2010year intervals. History of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> was assessed from questionnaires. We compared 5\u2010year changes in risk factors between women with and without <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>, by analysing longitudinal trends using generalised estimating equation analysis to estimate the effects of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> and mean age, adjusting for treatment, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), smoking and socio\u2010economic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Change over time in traditional cardiovascular risk factors, including systolic blood pressure (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) and diastolic blood pressure (<jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, total and high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) cholesterol for women with and without a history of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2703 women with normotensive pregnancies (mean age 40.5\u00a0years, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 10.4) and 689 women with a history of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> (mean age 38.4\u00a0years, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.5) were included. Compared with normotensive women, in women with a history of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SBP<\/jats:styled-content> was 2.8\u00a0mmHg higher (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u20133.9), <jats:styled-content style=\"fixed-case\">DBP<\/jats:styled-content> was 2.3\u00a0mmHg higher (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.6\u20133.0) and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was 0.7\u00a0kg\/m<jats:sup>2<\/jats:sup> higher (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.4\u20131.1). Total cholesterol (\u22120.05; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.1 to 0.0) and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol (0.02; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.0 to 0.1) were similar in both groups. No difference in annual change in blood pressure or in the other risk factors was observed between women with and without a history of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with a history of <jats:styled-content style=\"fixed-case\">HPD<\/jats:styled-content> have higher levels of <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> compared with normotensive women, but the increase with ageing is similar in both groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12254","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T20:49:12Z","timestamp":1367527752000},"page":"1333-1339","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Longitudinal analysis of cardiovascular risk parameters in women with a history of hypertensive pregnancy disorders: the <scp>D<\/scp>oetinchem <scp>C<\/scp>ohort <scp>S<\/scp>tudy"],"prefix":"10.1111","volume":"120","author":[{"given":"JT","family":"Drost","sequence":"first","affiliation":[{"name":"Department of Cardiology Isala Klinieken Zwolle the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YT","family":"van der Schouw","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AHEM","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre St Radboud Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WMM","family":"Verschuren","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht the Netherlands"},{"name":"National Institute of Public Health and the Environment (RIVM) Bilthoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.098"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000218683.97338.ea"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2291"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.156810"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05112-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00733.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67726-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044784"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.06.042"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-100100136"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.08.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000258595.09320.eb"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2719"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200312000-00002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943407"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000074428.11168.EE"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820faaf8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00114-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00347-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym292"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1741826711421079"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181bb0dfc"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.12254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:20:59Z","timestamp":1696321259000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.12254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,2]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/1471-0528.12254"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.12254","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,2]]},"assertion":[{"value":"2013-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}