{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:44:40Z","timestamp":1773773080543,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation Cassa di Risparmio di Padova e Rovigo"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To present the results of the first 2\u00a0years of a human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) test\u2010based screening programme outside the research context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Population\u2010based cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>A cervical service screening programme in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>taly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women aged 25\u201364\u00a0years invited to screening from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2009 to April 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible women were invited to undergo an <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test: those with a negative <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test went on to the next screening episode; those with a positive <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> went on to triage with a <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ap smear. Women with positive cytology (i.e. positive for atypical squamous cells of undetermined significance or worse, <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>+) were referred to colposcopy, whereas those with negative cytology were referred to repeat <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing 1\u00a0year later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Participation rate, positivity at <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and at triage, referral rate to colposcopy, positive predictive value for cervical intraepithelial neoplasia grade 2+ (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+) at colposcopy, and detection rate for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participation increased compared with the previous <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ap programme (60.6 versus 43.9%). The <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity rate was 7.0; 39.6% of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ap smears were scored as positive, and therefore 2.8% of the women screened were referred for immediate colposcopy. The compliance of women who scored positive for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and negative for <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ap for repeat <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing at 12\u00a0months was 78.6%, and the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity rate was 56.6%. The overall referral rate to colposcopy was 4.6%. The overall detection rate for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ was 4.5 versus 1.5% of the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ap programme (25\u201334\u00a0years, 8.2%; 35+\u00a0years, 3.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with the traditional Pap test, the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> programme recorded a higher response to invitation and an increased <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+. The most critical aspects were the reading of cytology in women that were positive for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and the increased workload at colposcopy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12272","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T09:09:47Z","timestamp":1371805787000},"page":"1260-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Use of a high\u2010risk human papillomavirus <scp>DNA<\/scp> test as the primary test in a cervical cancer screening programme: a population\u2010based cohort study"],"prefix":"10.1111","volume":"120","author":[{"given":"M","family":"Zorzi","sequence":"first","affiliation":[{"name":"Veneto Tumour Registry Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Del Mistro","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Oncology Unit Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Farruggio","sequence":"additional","affiliation":[{"name":"Department of Pathology Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"de' Bartolomeis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Frayle\u2010Salamanca","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Oncology Unit Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Baboci","sequence":"additional","affiliation":[{"name":"Immunology and Molecular Oncology Unit Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bertazzo","sequence":"additional","affiliation":[{"name":"Department of Prevention Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Pathology Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Fedato","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gennaro","sequence":"additional","affiliation":[{"name":"Department of Prevention Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MG","family":"Penon","sequence":"additional","affiliation":[{"name":"Department of Prevention Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cogo","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry Istituto Oncologico Veneto IRCCS Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Prevention Local Health Unit Monselice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70296-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70360-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61450-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073204"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70156-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2010.009092"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp471"},{"issue":"4","key":"e_1_2_7_10_1","first-page":"S1","article-title":"European guidelines for quality assurance in cervical cancer screening. 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