{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:21:03Z","timestamp":1789924863606,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the risk of adverse maternal and perinatal outcomes in women with antepartum bleeding of unknown origin (<jats:styled-content style=\"fixed-case\">ABUO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study based on data extracted from the Aberdeen Maternity and Neonatal Databank. Exposure was antepartum haemorrhage occurring after the first trimester not attributable to placenta praevia or placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Aberdeen Maternity Hospital, Aberdeen, Scotland, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>All primigravidae delivering between 1976 and 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analysed using univariate and multivariate statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Pre\u2010eclampsia, induced labour, mode of delivery, preterm delivery, postpartum haemorrhage, admission to neonatal unit, perinatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 1976 and 2010, there were 7517 women with ABUO and 68\u00a0423 women without ABUO in the cohort. Women with ABUO were more likely to be non\u2010smokers, belong to a lower social class, and have a higher body mass index. ABUO was a significant risk factor for induced labour (adjusted odds ratio, <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>,\u00a01.23; 95% CI 1.16\u20131.31), preterm delivery at &lt;37\u00a0weeks of gestation (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a02.30; 95% CI 2.11\u20132.50), and postpartum haemorrhage (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a01.15; 95% CI 1.06\u20131.25). There was no significant association detected with pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a00.93; 95% CI 0.83\u20131.05). Whereas there was an increased risk of low birthweight (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a00.90; 95% CI 0.79\u20131.03) and stillbirth (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a00.92; 95% CI 0.66\u20131.30) with ABUO on univariate analysis, once adjusted for confounding factors this risk was non\u2010significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancies complicated by <jats:styled-content style=\"fixed-case\">ABUO<\/jats:styled-content> are at a greater risk of preterm delivery and induced labour. There was no increase seen in perinatal mortality after adjusting for preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12464","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T09:58:37Z","timestamp":1381831117000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Maternal and perinatal consequences of antepartum haemorrhage of unknown origin"],"prefix":"10.1111","volume":"121","author":[{"given":"S","family":"Bhandari","sequence":"first","affiliation":[{"name":"Epidemiology Group Institute of Applied Health Sciences University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EA","family":"Raja","sequence":"additional","affiliation":[{"name":"Medical Statistics Team Institute of Applied Health Sciences University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology NHS Grampian Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Epidemiology Group Institute of Applied Health Sciences University of Aberdeen Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01398.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780303.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2008.09.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/10565"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000182881.53139.f7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.26719\/2000.6.2-3.457","article-title":"Outcomes of pregnancies complicated by early vaginal bleeding","volume":"6","author":"Arafa M","year":"2000","journal-title":"East Mediterr Health J"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb04500.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802038124"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0530-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01856.x"},{"key":"e_1_2_11_12_1","unstructured":"Aberdeen Maternity and Neonatal Databank (AMND).Aberdeen Maternity Neonatal Databank.2008; Available at: [www.abdn.ac.uk\/amnd\/]. 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