{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:50:48Z","timestamp":1776703848668,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare microcirculatory perfusion in women with severe pre\u2010eclampsia against that in healthy pregnant women, and secondly in women with severe pre\u2010eclampsia with or without <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome (haemolysis, elevated liver enzymes, and low platelets).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>otterdam, the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010three women with severe pre\u2010eclampsia and 23 healthy pregnant controls, matched for maternal and gestational age. Out of the 23 women with severe pre\u2010eclampsia, ten presented with <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microcirculation was analysed sublingually by a non\u2010invasive sidestream dark\u2010field imaging device (<jats:styled-content style=\"fixed-case\">SDF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Perfused vessel density (<jats:styled-content style=\"fixed-case\">PVD<\/jats:styled-content>), microcirculatory flow index (<jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content>), and heterogeneity index (<jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content>) were calculated for both small vessels (\u2205\u00a0&lt;\u00a020\u00a0\u03bcm; capillaries) and non\u2010small vessels (\u2205\u00a0&gt;\u00a020\u00a0\u03bcm; venules and arterioles).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between women with severe pre\u2010eclampsia and healthy controls. Women with pre\u2010eclampsia and <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome showed a reduced <jats:styled-content style=\"fixed-case\">PVD<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045), <jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008), and increased <jats:styled-content style=\"fixed-case\">HI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) for small vessels, as compared with women with pre\u2010eclampsia but without <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sidestream dark\u2010field is a novel, promising technique in obstetrics that permits the non\u2010invasive evaluation of microcirculation. We did not observe major differences in sublingual microcirculatory perfusion between women with severe pre\u2010eclampsia and healthy pregnant controls. In women with severe pre\u2010eclampsia, the presence of <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome is characterised by impaired capillary perfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12475","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T09:00:50Z","timestamp":1384160450000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Microcirculation in women with severe pre\u2010eclampsia and <scp>HELLP<\/scp> syndrome: a case\u2013control study"],"prefix":"10.1111","volume":"121","author":[{"given":"J","family":"Cornette","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Division of Obstetrics &amp; Prenatal Medicine Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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