{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:28:54Z","timestamp":1780104534844,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate a slower (compared with a standard) infusion rate of the loading dose of magnesium sulphate for preterm fetal neuroprotection as a strategy to reduce maternal adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>South Australian maternity hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fifty\u2010one women at &lt;30\u00a0weeks of gestation, where birth was planned or expected within 24\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women received a loading infusion of 4\u00a0g of magnesium sulphate over either 60 or 20\u00a0minutes (followed by maintenance of 1\u00a0g\/hour until birth, or for up to 24\u00a0hours).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Any maternal adverse effects associated with the infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 71% of women experienced adverse effects during the first hour of their infusion; the difference between groups was not significant [15\/25 (60%) 60\u2010minute loading; 21\/26 (81%) 20\u2010minute loading; risk ratio (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) 0.74; 95%\u00a0confidence interval (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.51\u20131.08]. Although no serious maternal complications occurred, adverse effects led to three women ceasing the loading treatment (1\/25 in the 60\u2010minute loading group; 2\/26 in the 20\u2010minute loading group; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a00.52; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.05\u20135.38). Women in the 60\u2010minute loading group experienced significantly less warmth and flushing at 20\u00a0minutes into the infusion (7\/25 in the 60\u2010minute loading group; 15\/26 in the 20\u2010minute loading group; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\u00a00.49; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.24\u20130.99). No other differences between groups for maternally reported and clinical adverse effects were shown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A slower rate of administering the loading dose of magnesium sulphate did not reduce the occurrence of maternal adverse effects overall. Flushing and warmth at 20\u00a0minutes into the infusion was reduced with a slower infusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12535","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T05:41:31Z","timestamp":1388986891000},"page":"595-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal adverse effects with different loading infusion rates of antenatal magnesium sulphate for preterm fetal neuroprotection: the <scp>IRIS<\/scp> randomised trial"],"prefix":"10.1111","volume":"121","author":[{"given":"ES","family":"Bain","sequence":"first","affiliation":[{"name":"Australian Research Centre for Health of Women and Babies Robinson Institute School of Paediatrics and Reproductive Health The University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PF","family":"Middleton","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Health of Women and Babies Robinson Institute School of Paediatrics and Reproductive Health The University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LN","family":"Yelland","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Health of Women and Babies Robinson Institute School of Paediatrics and Reproductive Health The University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PJ","family":"Ashwood","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Health of Women and Babies Robinson Institute School of Paediatrics and Reproductive Health The University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Crowther","sequence":"additional","affiliation":[{"name":"Australian Research Centre for Health of Women and Babies Robinson Institute School of Paediatrics and Reproductive Health The University of Adelaide Adelaide Australia"},{"name":"The Liggins Institute The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.020396"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.1.134"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706475"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0091"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?","volume":"95","author":"Nelson KB","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389200700113"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2669"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01165.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01162.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.123544"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801187"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004661.pub3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000025.pub2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007388.pub2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001060"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000940.pub2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038040-00002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92225-X"},{"key":"e_1_2_7_21_1","first-page":"145","article-title":"Cardiopulmonary arrest after the administration of magnesium sulphate. A case report","volume":"67","author":"Richards A","year":"1985","journal-title":"S Afr Med J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009302"},{"key":"e_1_2_7_23_1","volume-title":"Antenatal magnesium sulphate prior to preterm birth for neuroprotection of the fetus, infant and child: national clinical practice guidelines","author":"The Antenatal Magnesium Sulphate for Neuroprotection Guideline Development Panel","year":"2010"},{"key":"e_1_2_7_24_1","volume-title":"South Australian Perinatal Practice Guidelines. Chapter 96b Magnesium sulphate for neuroprotection of the fetus in women at risk of preterm birth","author":"South Australian Perinatal Practice Guidelines Workgroup","year":"2010"},{"key":"e_1_2_7_25_1","volume-title":"PSANZ Clinical Practice Guideline for Perinatal Mortality","author":"Flenady V","year":"2009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-32"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-4-200602210-00007"},{"key":"e_1_2_7_28_1","first-page":"681","article-title":"Effects of magnesium sulfate on toxemic patients in labor","volume":"49","author":"Young BK","year":"1977","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-195"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.12535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:02:04Z","timestamp":1695513724000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.12535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,6]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/1471-0528.12535"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.12535","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,6]]},"assertion":[{"value":"2013-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}