{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:10:59Z","timestamp":1787893859061,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>), and to examine the role of hyperandrogenaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Singleton pregnancies in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> identified at a private fertility clinic during 1997\u20132010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 459 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and a background population of 5409 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Obstetric outcomes were extracted from national Danish registries and odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Risk of pre\u2010eclampsia, preterm delivery, and small for gestational age offspring in the entire <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> population and in a subsample with hyperandrogenaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> had an increased risk of preterm delivery &lt;37\u00a0weeks of gestation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.28; 95% confidence interval, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.51\u20133.45; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The elevated risk was confined to hyperandrogenic women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>: preterm delivery before 37\u00a0weeks of gestation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.78; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.62\u20134.77; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and was not seen in normoandrogenic women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.35; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.54\u20133.39; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.52). The overall risk of pre\u2010eclampsia was not elevated (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.69; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.99\u20132.88; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.41; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.26\u20134.58; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The risk of small for gestational age offspring was similar in all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> who had a two\u2010fold increased risk of preterm delivery and pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12558","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T06:06:46Z","timestamp":1389593206000},"page":"575-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Increased risk of preterm delivery and pre\u2010eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia"],"prefix":"10.1111","volume":"121","author":[{"given":"KV","family":"Naver","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Grinsted","sequence":"additional","affiliation":[{"name":"The Fertility Clinic Trianglen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SO","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Immunology, and Genetics Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PL","family":"Hedley","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Immunology, and Genetics Statens Serum Institut Copenhagen Denmark"},{"name":"Department of Biomedicine University of Stellenbosch Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FS","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Immunology, and Genetics Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Nilas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Hvidovre University Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6309"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(80)90044-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_7_8_1","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen LB","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-011-0290-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.194"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des193"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067719"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.04.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem028"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.540600"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0853"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.06.038"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.05.035"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.05.049"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61041-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des145"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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