{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:15:26Z","timestamp":1791472526224,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>More women with schizophrenia are becoming pregnant, such that contemporary data are needed about maternal and newborn outcomes in this potentially vulnerable group. We aimed to quantify maternal and newborn health outcomes among women with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Population based in <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ntario, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anada, from 2002 to 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Ontario women aged 15\u201349\u00a0years who gave birth to a liveborn or stillborn singleton infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with schizophrenia (<jats:italic>n\u00a0<\/jats:italic>=\u00a01391) were identified based on either an inpatient diagnosis or two or more outpatient physician service claims for schizophrenia within 5\u00a0years prior to conception. The reference group comprised 432\u00a0358 women without diagnosed mental illness within the 5\u00a0years preceding conception in the index pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary maternal outcomes were gestational diabetes mellitus, gestational hypertension, pre\u2010eclampsia\/eclampsia, and venous thromboembolism. The primary neonatal outcomes were preterm birth, and small and large birthweight for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LGA<\/jats:styled-content>). Secondary outcomes included additional key perinatal health indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Schizophrenia was associated with a higher risk of pre\u2010eclampsia (adjusted odds ratio, a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.84; 95% confidence interval, 95% CI 1.28\u20132.66), venous thromboembolism (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.72, 95% CI 1.04\u20132.85), preterm birth (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.75, 95% CI 1.46\u20132.08), SGA (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.49, 95% CI 1.19\u20131.86), and LGA (a<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.53, 95% CI 1.17\u20131.99). Women with schizophrenia also required more intensive hospital resources, including operative delivery and admission to a maternal intensive care unit, paralleled by higher neonatal morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with schizophrenia are at higher risk of multiple adverse pregnancy outcomes, paralleled by higher neonatal morbidity. Attention should focus on interventions to reduce the identified health disparities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12567","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T06:34:47Z","timestamp":1390286087000},"page":"566-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["Maternal and newborn outcomes among women with schizophrenia: a retrospective population\u2010based cohort study"],"prefix":"10.1111","volume":"121","author":[{"given":"SN","family":"Vigod","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Women's College Research Institute University of Toronto Toronto Ontario Canada"},{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Kurdyak","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"},{"name":"Centre for Addiction and Mental Health Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CL","family":"Dennis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Women's College Research Institute University of Toronto Toronto Ontario Canada"},{"name":"Faculty of Nursing University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gruneir","sequence":"additional","affiliation":[{"name":"Women's College Research Institute University of Toronto Toronto Ontario Canada"},{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Newman","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MV","family":"Seeman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Rochon","sequence":"additional","affiliation":[{"name":"Women's College Research Institute University of Toronto Toronto Ontario Canada"},{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"},{"name":"Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GM","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"},{"name":"Faculty of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Toronto Toronto Ontario Canada"},{"name":"Sunnybrook Research Institute Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JG","family":"Ray","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Evaluative Sciences Toronto Ontario Canada"},{"name":"Faculty of Medicine University of Toronto Toronto Ontario Canada"},{"name":"Keenan Research Centre St. Michael's Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204700904"},{"issue":"13","key":"e_1_2_6_3_1","first-page":"7S","article-title":"Clinical practice guidelines. 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