{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:41:19Z","timestamp":1781624479956,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To conduct enhanced surveillance for signals of teratogenesis following use of the neuraminidase inhibitors zanamivir and oseltamivir in the treatment or post\u2010exposure prophylaxis of 2009 A\/H1N1 influenza during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study, using national surveillance data collected by the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> Teratology Information Service (<jats:styled-content style=\"fixed-case\">UKTIS<\/jats:styled-content>) during the 2009 A\/H1N1 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>United Kingdom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Pregnant women who were reported to <jats:styled-content style=\"fixed-case\">UKTIS<\/jats:styled-content> by healthcare professionals seeking advice about exposure to zanamivir and oseltamivir or to other non\u2010teratogenic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnancy outcomes were collected for prospectively reported pregnancies exposed to zanamivir (<jats:italic>n<\/jats:italic>\u00a0=\u00a0180) or oseltamivir (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), and compared with a reference group of 575 prospectively reported pregnancies exposed to non\u2010teratogenic drugs over the same period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Rates of major congenital malformation, preterm delivery and low birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in overall rates of major malformation in live\u2010born infants [adjusted odds ratios (aOR): zanamivir 0.37 (95% confidence interval 0.02\u20132.70); oseltamivir aOR 0.81 (0.05, 14.15)], preterm delivery [aOR: zanamivir 0.95 (0.45, 1.89); oseltamivir aOR 1.68 (0.38, 5.38)] or low birth weight [aOR: zanamivir 0.94 (0.25, 2.90); oseltamivir aOR 4.12 (0.59, 17.99)] were observed following exposure at any gestation. No major malformations were reported in 37 zanamivir or eight oseltamivir first trimester exposures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These surveillance data do not provide a signal that use of zanamivir or oseltamivir in pregnancy is associated with an increased risk of the adverse pregnancy outcomes studied but the data are too limited to state conclusively that there is no increase in risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12640","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T07:42:39Z","timestamp":1394178159000},"page":"901-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A\/H1N1 pandemic: a national prospective surveillance study"],"prefix":"10.1111","volume":"121","author":[{"given":"HJ","family":"Dunstan","sequence":"first","affiliation":[{"name":"United Kingdom Teratology Information Service Wolfson Unit Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Mill","sequence":"additional","affiliation":[{"name":"School of Biology Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Stephens","sequence":"additional","affiliation":[{"name":"United Kingdom Teratology Information Service Wolfson Unit Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LM","family":"Yates","sequence":"additional","affiliation":[{"name":"United Kingdom Teratology Information Service Wolfson Unit Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"},{"name":"Institute of Human Genetics International Centre for Life Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHL","family":"Thomas","sequence":"additional","affiliation":[{"name":"United Kingdom Teratology Information Service Wolfson Unit Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"},{"name":"Wolfson Unit of Clinical Pharmacology Institute of Cellular Medicine and Medical Toxicology Centre Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3214"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1712"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20369"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta14340-02"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12066"},{"key":"e_1_2_6_7_1","unstructured":"StevensonM NunesT SanchezJ ThorntonR.epiR: Functions for analysing epidemiological data R package version 09\u201027 2010http:\/\/CRANR-projectorg\/package=epiR. 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