{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:47:29Z","timestamp":1788173249063,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Objective<\/jats:title>To study colposcopic performance in diagnosing high\u2010grade cervical intraepithelial neoplasia or cervical cancer (CIN<\/jats:styled-content>2+ and CIN<\/jats:styled-content>3+) using colposcopic characteristics and high\u2010risk human papillomavirus (hrHPV<\/jats:styled-content>) genotyping.<\/jats:p><\/jats:sec>Design<\/jats:title>Cross\u2010sectional multicentre study.<\/jats:p><\/jats:sec>Setting<\/jats:title>Two colposcopy clinics in T<\/jats:styled-content>he N<\/jats:styled-content>etherlands and S<\/jats:styled-content>pain.<\/jats:p><\/jats:sec>Population<\/jats:title>Six hundred and ten women aged 17\u00a0years and older referred for colposcopy because of abnormal cytology.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cervical smear was obtained. Colposcopists identified the worst lesion, graded their impression and scored the colposcopic characteristics of the lesions. Up to four biopsies were collected, including one biopsy from visually normal tissue.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>CIN<\/jats:styled-content>2+ and CIN<\/jats:styled-content>3+, positive for HPV<\/jats:styled-content>16 or other high\u2010risk HPV<\/jats:styled-content> types (non\u201016 hrHPV<\/jats:styled-content>\u2010positive).<\/jats:p><\/jats:sec>Results<\/jats:title>The mean age in HPV<\/jats:styled-content>16\u2010positive CIN<\/jats:styled-content>2+ women was 35.1\u00a0years compared with 39.1\u00a0years in women with other hrHPV<\/jats:styled-content> types (P\u00a0<\/jats:italic>=\u00a00.002). Sensitivity for colposcopy to detect CIN<\/jats:styled-content>2+ was 87.9% (95%CI<\/jats:styled-content> 83.2\u201391.5), using colposcopic cut\u2010off of \u2018any abnormality\u2019. The remaining CIN<\/jats:styled-content>2+ were found by a biopsy from visually normal tissue or endocervical curettage (ECC<\/jats:styled-content>). Detection of CIN<\/jats:styled-content>2+ by lesion\u2010targeted biopsies was not different between HPV<\/jats:styled-content>16\u2010positive women [119\/135; 88.1% (95%CI<\/jats:styled-content> 81.2\u201392.9)] and non\u201016 hrHPV<\/jats:styled-content>\u2010positive women [100\/115; 87.0% (95%CI<\/jats:styled-content> 79.1\u201392.3); P\u00a0<\/jats:italic>=\u00a00.776]. In multivariate analysis, \u2018acetowhitening\u2019 [odds ratio (OR<\/jats:styled-content>) 1.91, 95%CI<\/jats:styled-content> 1.56\u20133.17], \u2018time of appearance\u2019 (OR<\/jats:styled-content> 1.95, 95%CI<\/jats:styled-content> 1.21\u20133.15) and \u2018lesion >25% of visible cervix\u2019 (OR<\/jats:styled-content> 2.25, 95%CI<\/jats:styled-content> 1.44\u20133.51) were associated with CIN<\/jats:styled-content>2+.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this population following European screening practice, HPV<\/jats:styled-content>16\u2010related CIN<\/jats:styled-content>2+ lesions were detected at younger age and showed similar colposcopic impression as non\u201016 hrHPV<\/jats:styled-content> high\u2010grade lesions. There was no relationship between any of the colposcopic characteristics and HPV<\/jats:styled-content>16 status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12668","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T20:59:04Z","timestamp":1391547544000},"page":"1117-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The impact of human papillomavirus genotype on colposcopic appearance: a cross\u2010sectional analysis"],"prefix":"10.1111","volume":"121","author":[{"given":"J","family":"van der Marel","sequence":"first","affiliation":[{"name":"Department of Research and Development DDL Diagnostic Laboratory Rijswijk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"van Baars","sequence":"additional","affiliation":[{"name":"Department of Research and Development DDL Diagnostic Laboratory Rijswijk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WGV","family":"Quint","sequence":"additional","affiliation":[{"name":"Department of Research and Development DDL Diagnostic Laboratory Rijswijk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Berkhof","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"del Pino","sequence":"additional","affiliation":[{"name":"Institut Clinic of Gynecology, Obstetrics and Neonatology Hospital Cl\u00ednic\u2010Institut d\u2032Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Torn\u00e9","sequence":"additional","affiliation":[{"name":"Institut Clinic of Gynecology, Obstetrics and Neonatology Hospital 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