{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:19Z","timestamp":1791404899211,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Objective<\/jats:title>\n \n To examine the association between maternal hyper\u2010 and hypothyroidism and the risk of attention deficit hyperactivity disorder (\n ADHD<\/jats:styled-content>\n ) and autism spectrum disorder (\n ASD<\/jats:styled-content>\n ) in the child.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A population\u2010based cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Singletons liveborn in\n D<\/jats:styled-content>\n enmark between 1991 and 2004.\n <\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n A total of 857\u00a0014 singletons alive and living in\n D<\/jats:styled-content>\n enmark at the age of 3\u00a0years.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Information on the diagnosis and\/or treatment of maternal thyroid disease and the neurodevelopmental disorders\n ADHD<\/jats:styled-content>\n and\n ASD<\/jats:styled-content>\n in the child was obtained from\n D<\/jats:styled-content>\n anish nationwide registers. The Cox proportional hazards model was used to estimate the hazard ratio (\n HR<\/jats:styled-content>\n ) with 95% confidence interval (95%\n CI<\/jats:styled-content>\n ) for risk of\n ADHD<\/jats:styled-content>\n and\n ASD<\/jats:styled-content>\n in children born to mothers with thyroid dysfunction, adjusting for potential confounding factors.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n ADHD and\n ASD<\/jats:styled-content>\n in the child.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Altogether, 30\u00a0295 singletons (3.5%) were born to mothers with thyroid dysfunction. Maternal hyperthyroidism diagnosed and treated for the first time after the birth of the child increased the risk of\n ADHD<\/jats:styled-content>\n in the child (adjusted\n HR<\/jats:styled-content>\n 1.23; 95%\n CI<\/jats:styled-content>\n 1.05\u20131.44), whereas hypothyroidism increased the risk of\n ASD<\/jats:styled-content>\n (adjusted\n HR<\/jats:styled-content>\n 1.34; 95%\n CI<\/jats:styled-content>\n 1.14\u20131.59). No significant association was seen for maternal diagnosis and treatment prior to the birth of the child.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Children born to mothers diagnosed and treated for the first time for thyroid dysfunction after their birth may have been exposed to abnormal levels of maternal thyroid hormone already present during the pregnancy, and this untreated condition could increase the risk of specific neurodevelopmental disorders in the child.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.12681","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T02:49:28Z","timestamp":1394419768000},"page":"1365-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a\n D<\/scp>\n anish nationwide cohort study"],"prefix":"10.1111","volume":"121","author":[{"given":"SL","family":"Andersen","sequence":"first","affiliation":[{"name":"Departments of Clinical Medicine and Endocrinology Aalborg University and Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Departments of Clinical Medicine and Endocrinology Aalborg University and Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CS","family":"Wu","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Olsen","sequence":"additional","affiliation":[{"name":"Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2000.0185"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(98)80012-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s3511"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1330390"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.09.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02068"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1155"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410801"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00639.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106104"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp032387"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-012-0359-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0206"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1302"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1021"},{"key":"e_1_2_6_17_1","first-page":"441","article-title":"The Danish civil registration system. 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