{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:50:38Z","timestamp":1778629838767,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate gonadal function and uterine volume in a cohort of female survivors treated by chemotherapy, radiotherapy, and\/or stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) for childhood malignant and non\u2010malignant diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>An observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>S.\u00a0Matteo Hospital, Pavia, Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 135 female survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical, hormonal, and ultrasonographic evaluation. Thirty\u2010three patients (24%) had non\u2010malignant haematologic diseases (thalassaemia or sickle cell anaemia), 68 (50%) had leukaemia, 23 (17%) had lymphomas, and 11 (8%) had solid tumours. In total, 106 patients had received <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, preceded by a conditioning regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Anti\u2010M<jats:italic>\u00fc<\/jats:italic>llerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) and Inhibin\u2013B, and uterine volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median concentrations of <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> and Inhibin\u2013B in the entire cohort were 0.12\u00a0ng\/ml (interquartile range, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 0.1\u20130.5\u00a0ng\/ml) and 3.5\u00a0pg\/ml (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a00.1\u201313.2\u00a0pg\/ml), respectively. In a stepwise ordered logistic regression analysis, conventional chemotherapy for the treatment of malignancies, as opposed to total body irradiation (<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>), was the only oncologically significant predictor of increased <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> levels (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a04.8, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.9\u201312, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Conditioning treatment before or after menarche did not influence <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> concentrations (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.24). The best predictor of reduced uterine volume was <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content> during the preparation for the allograft (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a03.5, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20138.4, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.006). Increasing age at treatment (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.86, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.77\u20130.95, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.04), chemotherapy, as opposed to other treatments (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.09, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.03\u20130.28, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), and solid tumours as opposed to either leukaemia\/lymphomas or non\u2010malignant diseases (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a00.2, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.07\u20130.56, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.002) were associated with larger uterine volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conditioning therapies for <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>, including <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>, had the worst effects on uterine volume and gonadal reserve. Increasing age at treatment and conventional chemotherapy were associated with less detrimental effects on uterine volume.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12715","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T08:12:42Z","timestamp":1395648762000},"page":"856-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gonadal and uterine function in female survivors treated by chemotherapy, radiotherapy, and\/or bone marrow transplantation for childhood malignant and non\u2010malignant diseases"],"prefix":"10.1111","volume":"121","author":[{"given":"F","family":"Beneventi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology IRCSS S. 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