{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:48:28Z","timestamp":1790819308328,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"crossref","award":["R129-A11803"],"award-info":[{"award-number":["R129-A11803"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to describe the use of antibiotics in a national population\u2010based cohort of pregnant Danish women between 2000 and 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Register\u2010based, population\u2010wide, cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Denmark, from 2000 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>All pregnancies among Danish residents during the period 2000\u20132010 were included for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the Danish Medical Birth Registry, the Danish National Patient Registry, and the Registry of Medicinal Product Statistics. The filled prescriptions for systemic antibacterial, antimycotic, and antiviral drugs, as well as intravaginally applied antibiotics, were analysed. Associations with demographic variables were assessed using multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Filled prescriptions for antibiotic drugs during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 987\u00a0973 pregnancies in Denmark from 2000 to 2010; 38.9% of women with a delivery and 14.8% of women with a miscarriage or termination of pregnancy had one or more antibiotic treatments during pregnancy. Systemic antibacterial drugs were the most frequently used drug group, with filled prescriptions for 33.4% of all deliveries and 12.6% of all abortions. This proportion increased from 28.4% in 2000 to 37.0% in 2010 among deliveries. The biggest change was seen for pivmecillinam, which increased among deliveries from 6.3% in 2000 to 19.5% in 2010. Obese (odds ratio 1.51; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.47\u20131.56), young (odds ratio 1.35; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.30\u20131.39), and low\u2010educated women (odds ratio 1.37; 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.35\u20131.1.39) tended to fill more prescriptions of antibiotics during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, the number of women who filled prescriptions of antibiotics increased during the 11\u2010year study period. In 2010, at least 41.5% of all deliveries were exposed to antibiotic therapy during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12806","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T05:26:44Z","timestamp":1398230804000},"page":"988-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Increasing use of antibiotics in pregnancy during the period 2000\u20132010: prevalence, timing, category, and demographics"],"prefix":"10.1111","volume":"121","author":[{"given":"A","family":"Broe","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Chemistry &amp; Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RF","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Odense University Hospital Odense Denmark"},{"name":"Division of Surgery University College London Northwick Park Institute of Medical Research Campus London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JS","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Damkier","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Institute of Public Health University of Southern Denmark Odense Denmark"},{"name":"Department of Clinical Chemistry &amp; Pharmacology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr453"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053327"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00305.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12411"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.144"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.27"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328349b166"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.11.026"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03102.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S16305"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2159"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17747"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2179"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061148"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1336"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1225"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3492"},{"key":"e_1_2_7_20_1","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen LB","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_22_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems","author":"World Health Organization","year":"1992"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki147"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394715"},{"key":"e_1_2_7_27_1","unstructured":"The Danish Society of Obstetrics and Gynaecology.Obstetric guidelines. 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