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Survival and quality of life (QoL) for those with cerebral palsy were compared with age\u2010matched individuals representative of the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> general population, in order to estimate the number of quality\u2010adjusted life years (<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s) lost following asphyxia\u2010related cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Incidence of asphyxia\u2010related cerebral palsy, <jats:styled-content style=\"fixed-case\">QALYS<\/jats:styled-content>, QoL, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 207 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0169\u2013245) cases of asphyxia\u2010related cerebral palsy were projected amongst <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> children born during the year 2014, with approximately 15.2\u00a0<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s lost per case. If these results held true in a real birth cohort, 3142 (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a02321\u20133963) <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s would be lost as a consequence of asphyxia\u2010related cerebral palsy, a loss valued by the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> National Health Service at \u00a362.9\u00a0m (95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u00a346.4\u201379.3\u00a0m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cerebral palsy following intrapartum asphyxiation leads to significant reductions in QoL and survival; however, this may often be prevented. For those with <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>\u00a01 and <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>\u00a02 cerebral palsy (Gross Motor Function Classification System), lifetime <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s accrued largely resemble those experienced by the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> general population, whereas for <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>\u00a03 and <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>\u00a04 <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s are reduced considerably, and are negative in the case of <jats:styled-content style=\"fixed-case\">GMFCS<\/jats:styled-content>\u00a05.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12897","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T09:52:32Z","timestamp":1401789152000},"page":"1720-1728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The incidence and implications of cerebral palsy following potentially avoidable obstetric complications: a preliminary burden of disease study"],"prefix":"10.1111","volume":"121","author":[{"given":"S","family":"Leigh","sequence":"first","affiliation":[{"name":"Liverpool Health Economics Management School University of Liverpool Liverpool UK"},{"name":"Lifecode<sup>\u00ae<\/sup>, the Old Vicarage Lindley Huddersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Granby","sequence":"additional","affiliation":[{"name":"Liverpool Health Economics Management School University of Liverpool Liverpool UK"},{"name":"Lifecode<sup>\u00ae<\/sup>, the Old Vicarage Lindley Huddersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Turner","sequence":"additional","affiliation":[{"name":"Liverpool Women's NHS Foundation Trust Merseyside UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wieteska","sequence":"additional","affiliation":[{"name":"The Advanced Life Support Group ALSG Centre for Training &amp; Development Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Haycox","sequence":"additional","affiliation":[{"name":"Liverpool Health Economics Management School University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Collins","sequence":"additional","affiliation":[{"name":"Liverpool Health Economics Management School University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02565.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1542\/peds.85.6.961","article-title":"Current and potentially new management strategies for perinatal hypoxic\u2010ischemic encephalopathy","volume":"85","author":"Vannucci RC","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_8_4_1","unstructured":"The Clinical Negligence Scheme for Trusts \u2013 Why CNST Rules. 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