{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:26:00Z","timestamp":1777458360818,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G9700808"],"award-info":[{"award-number":["G9700808"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NHS England and NHS Scotland"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the rate of cervical intraepithelial neoplasia grade 2 (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+) in women with low grade cervical cytology and a normal colposcopy examination over 3\u00a0years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study within a randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> Cervical Screening Programmes in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rampian, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ayside and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ottingham.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eight hundred and eighty\u2010four women aged 20\u201359\u00a0years with borderline nuclear abnormalities (<jats:styled-content style=\"fixed-case\">BNA<\/jats:styled-content>) or mild dyskaryosis with a normal and adequate colposcopy examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples at baseline were tested for 14 high\u2010risk (Hr) types using <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>5+6+ methodology and for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> 16 and 18 using type\u2010specific primers. Women were followed up post\u2010colposcopy by cervical cytology at 6\u2010month intervals in primary care. After 3\u00a0years, women were invited for an exit colposcopy examination and underwent <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> if any colposcopic abnormality was identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Absolute and relative risks of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ during follow\u2010up and\/or at exit colposcopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 36\u00a0years. The absolute risk of developing <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ within 3\u00a0years was 1.86 per 100 woman years and for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+, 0.64 per 100 woman years. One microinvasive cancer was identified. The relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) was highest for women with initial mild dyskaryosis who were <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>r<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 5.86, 95% confidence interval 2.53\u201313.56) compared with women with <jats:styled-content style=\"fixed-case\">BNA<\/jats:styled-content> who were <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>r<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For women with low grade cervical cytology, the risk of a high grade <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> within 3\u00a0years of a normal colposcopy examination is low. Women can be reassured that, even with a positive <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test, the risk of developing <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 or worse is sufficiently low to return to the routine 3\u2010year recall.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12932","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T05:44:53Z","timestamp":1403243093000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Management of women with low grade cytology: how reassuring is a normal colposcopy examination?"],"prefix":"10.1111","volume":"122","author":[{"given":"ME","family":"Cruickshank","sequence":"first","affiliation":[{"name":"Obstetrics &amp; Gynaecology University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SC","family":"Cotton","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology University of Aberdeen Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Sharp","sequence":"additional","affiliation":[{"name":"National Cancer Registry Ireland Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Smart","sequence":"additional","affiliation":[{"name":"Department of Pathology Aberdeen Royal Infirmary Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LG","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Hull Kingston upon Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Community Medicine University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the TOMBOLA Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02263.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68181-6"},{"key":"e_1_2_10_4_1","volume-title":"Colposcopy and Programme Management: Guidelines for the NHS Cervical Screening Programme","author":"NHSCSP 20","year":"2010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181839645"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01065.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7251.1693"},{"key":"e_1_2_10_8_1","first-page":"623","article-title":"Normal colposcopy following abnormal Pap smear evoking LGSIL: a follow\u2010up study","volume":"25","author":"Kourounis G","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.053"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.091"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2006.04.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.3.791-795.1997"},{"key":"e_1_2_10_13_1","first-page":"20","article-title":"Incidence of CIN grade 2 or worse in colposcopy\u2010negative women with low grade cytological abnormalities","volume":"1471","author":"Kelly RS","year":"2011","journal-title":"BJOG"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X578007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.461"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.456"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2005.00301.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13116.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2548"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23276"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-011-0280-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02389.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.049"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27577"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.12932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:57:42Z","timestamp":1696355862000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/1471-0528.12932"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.12932","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]},"assertion":[{"value":"2014-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}