{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:34:14Z","timestamp":1769816054808,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess site of disease on preoperative computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) to predict surgical debulking in patients with ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two\u2010phase retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>West London Gynaecological Cancer Centre, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women with stage 3 or 4, ovarian, fallopian or primary peritoneal cancer undergoing cytoreductive surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preoperative <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> images were reviewed by experienced radiologists to assess the presence or absence of disease at predetermined sites. Multivariable stepwise logistic regression models determined sites of disease which were significantly associated with surgical outcomes in the test (<jats:italic>n<\/jats:italic>\u00a0=\u00a0111) and validation (<jats:italic>n<\/jats:italic>\u00a0=\u00a070) sets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Sensitivity and specificity of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in predicting surgical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stepwise logistic regression identified that the presence of lung metastasis, pleural effusion, deposits on the large\u2010bowel mesentery and small\u2010bowel mesentery, and infrarenal para\u2010aortic nodes were associated with debulking status. Logistic regression determined a surgical predictive score which was able to significantly predict suboptimal debulking (<jats:italic>n<\/jats:italic>\u00a0=\u00a094, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) with an area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) of 0.749 (95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 0.652, 0.846) and a sensitivity of 69.2%, specificity of 71.4%, positive predictive value of 75.0% and negative predictive value of 65.2%. These results remained significant in a recent validation set. There was a significant difference in residual disease volume in the test and validation sets (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in keeping with improved optimal debulking rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of disease at some sites on preoperative <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan is significantly associated with suboptimal debulking and may be an indication for a change in surgical planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.12992","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T05:40:49Z","timestamp":1407217249000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Radiological predictors of cytoreductive outcomes in patients with advanced ovarian 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