{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:18:09Z","timestamp":1778635089795,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ludwig Boltzmann Gesellschaft"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Screening for cervical cancer precursors by Papanicolaou cytology is a public health success story; however, its low sensitivity entails unnecessary referrals to colposcopy of healthy women with equivocal (<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>) or mild dysplasia (<jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>) cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the accuracy of p16\/Ki\u201067 immuno\u2010testing for triage of low grade cervical cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>We systematically searched Medline, Embase, <jats:styled-content style=\"fixed-case\">CRD<\/jats:styled-content> and Cochrane databases, and handsearched key references.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Eligible studies included women with <jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content> cervical cytology who had undergone p16\/Ki\u201067 testing and subsequent verification by colposcopy\u2010directed biopsies and histologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>We extracted data on patient characteristics and test conduct, diagnostic accuracy measures and assessed the methodological quality of the studies. R software was used to perform a bivariate analysis of test performance data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Five eligible studies were identified. Four of the studies had high risk of bias. In the <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content> subgroup, the sensitivity of p16\/Ki\u201067 testing ranged from 0.86 to 0.98, compared with 0.92\u20130.96 of high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing (hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>); specificity ranged from 0.43 to 0.68 versus 0.19 to 0.37, respectively. In the <jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content> subgroup, sensitivity ranged from 0.64 to 0.92 (p16\/Ki67 test) versus 0.91 to 0.97 (hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>); specificity ranged from 0.53 to 0.81 versus 0.26 to 0.44, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Authors' conclusions<\/jats:title><jats:p>p16\/Ki\u201067 testing cannot be recommended for triage women with <jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content> cytology due to insufficient high\u2010quality evidence. Further studies on test performance and the impact of p16\/Ki\u201067\u2010based triage on health outcomes are needed for a definitive evaluation of its clinical utility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13076","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T06:27:53Z","timestamp":1410416873000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A systematic review of p16\/Ki\u201067 immuno\u2010testing for triage of low grade cervical cytology"],"prefix":"10.1111","volume":"122","author":[{"given":"A","family":"Kisser","sequence":"first","affiliation":[{"name":"Ludwig Boltzmann Institute for Health Technology Assessment Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Zechmeister\u2010Koss","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Health Technology Assessment Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-35"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285423c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000296488.85807.b3"},{"key":"e_1_2_7_5_1","first-page":"20","article-title":"Leitlinie f\u00fcr die Diagnose und Therapie von Cervikalen Intraepithelialen Neoplasien (CIN) und Mikrokarzinomen der Cervix uteri","volume":"23","author":"Breitenecker G","year":"2005","journal-title":"Speculum Z Gyn\u00e4kol Geburtshlf"},{"key":"e_1_2_7_6_1","volume-title":"Empfehlungen der AG\u2010CPC zur Kolposkopie bei Erkrankungen des unteren Genitaltraktes der Frau. 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