{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:16:49Z","timestamp":1787239009496,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Objective<\/jats:title>\n \n To study the prevalence of metabolic syndrome in women after a pregnancy complicated by pre\u2010eclampsia or small\u2010for\u2010gestational\u2010age (\n SGA<\/jats:styled-content>\n ), both epitomes of placental syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single tertiary centre for maternal medicine in the Netherlands.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n Women with a history of pre\u2010eclampsia in absence of\n SGA<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u00a0=\u00a0742) or pregnancy complicated by normotensive\n SGA<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u00a0=\u00a0147) between 1996 and 2010.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Women were routinely screened for underlying cardiometabolic and cardiovascular risk factors at least 6\u00a0months postpartum. Logistic regression analysis was used to calculate the odds ratio and adjusted odds ratio for each group. Adjustments were made for age, maternal height, smoking, parity, and interval between delivery and measurement.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Prevalence of the metabolic syndrome.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of the metabolic syndrome in our population was two\u2010fold higher for women with a history of pre\u2010eclampsia (13.9%) compared with women with a history of SGA (7.6%). Calculated odds ratios for metabolic syndrome, fasting insulin, HOMA, and microalbuminuria were all higher for women with a history of pre\u2010eclampsia compared with women with SGA. This difference persisted after adjustment for confounding factors: metabolic syndrome (adjusted odds ratio,\n aOR<\/jats:styled-content>\n \u00a02.11; 95%\u00a0confidence interval, 95% CI 1.00\u20134.47) and hyperinsulinaemia (\n aOR<\/jats:styled-content>\n 1.78; 95%\u00a0CI\u00a01.13\u20132.81) insulin resistance (HOMA\n IR<\/jats:sub>\n ;\n aOR<\/jats:styled-content>\n \u00a01.80; 95%\u00a0CI\u00a01.14\u20132.86). Microalbuminuria (\n aOR<\/jats:styled-content>\n \u00a01.58; 95%\u00a0CI 0.85\u20132.93) did not reach the level of significance after adjustment for confounding factors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A history of pre\u2010eclampsia, rather than\n SGA<\/jats:styled-content>\n , was associated with metabolic syndrome, suggesting that it relates to maternal rather than fetal etiology of placental syndrome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.13117","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T04:34:20Z","timestamp":1413434060000},"page":"1818-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Metabolic syndrome after pregnancies complicated by pre\u2010eclampsia or small\u2010for\u2010gestational\u2010age: a retrospective cohort"],"prefix":"10.1111","volume":"122","author":[{"given":"S","family":"Al\u2010Nasiry","sequence":"first","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ghossein\u2010Doha","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEJ","family":"Polman","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lemmens","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RR","family":"Scholten","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WM","family":"Heidema","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ","family":"Spaan","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEA","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Department of Obstetrics & Gynaecology Maastricht University Medical Centre Maastricht the 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