{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:46:26Z","timestamp":1747763186257},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Objective<\/jats:title>To compare two electrosurgical techniques, straight\u2010wire excision of transformation zone (SWETZ<\/jats:styled-content>) with large loop excision of transformation zone, as a cone procedure (LLETZ<\/jats:styled-content>\u2010cone), for the treatment of cervical intraepithelial neoplasia (CIN<\/jats:styled-content>), when disease is present at the cervical canal.<\/jats:p><\/jats:sec>Design<\/jats:title>Randomised controlled trial.<\/jats:p><\/jats:sec>Setting<\/jats:title>Two public hospitals, one in Rio de Janeiro, Brazil and one in Dublin, Ireland.<\/jats:p><\/jats:sec>Population<\/jats:title>One hundred and three women with indication to treat CIN<\/jats:styled-content> located at cervical canal.<\/jats:p><\/jats:sec>Methods<\/jats:title>Women were randomised to receive LLETZ<\/jats:styled-content>\u2010cone or SWETZ<\/jats:styled-content>.<\/jats:p><\/jats:sec>Outcomes<\/jats:title>Main outcome was the incidence of complete excision of disease at endocervical margin of the surgical specimen. Secondary outcomes were complete excision at ectocervical and stromal margins, time to complete the procedure, specimen fragmentation, blood loss and death after 1\u00a0year.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty\u2010two women were allocated to LLETZ<\/jats:styled-content>\u2010cone and 51 to SWETZ<\/jats:styled-content>. Ten women were lost for main outcome because of damaged specimens. Forty\u2010two women in the LLETZ<\/jats:styled-content>\u2010cone group had free endocervical margin versus 43 women in the SWETZ<\/jats:styled-content> group (relative risk 1.04, 95% confidence interval [95% CI] 0.87\u20131.25; P\u00a0<\/jats:italic>=\u00a00.64). For secondary outcomes related to margins, we observed a relative risk of 1.15 (95% CI 0.95\u20131.39; P\u00a0<\/jats:italic>=\u00a00.15) for ectocervical free margin. For free stromal margin, the relative risk was 1.07 (95% CI 0.89\u20131.29; P\u00a0<\/jats:italic>=\u00a00.47). No death was observed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study was inconclusive; SWETZ<\/jats:styled-content> and LLETZ<\/jats:styled-content>\u2010cone were equally effective to treat endocervical disease, with no difference in protecting against margin involvement. Higher, but not severe, blood loss and longer surgical time were observed in the SWETZ<\/jats:styled-content> group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13200","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T06:57:16Z","timestamp":1418799436000},"page":"552-557","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Large loop versus straight\u2010wire excision of the transformation zone for treatment of cervical intraepithelial neoplasia: a randomised controlled trial of electrosurgical techniques"],"prefix":"10.1111","volume":"122","author":[{"given":"MJ","family":"Camargo","sequence":"first","affiliation":[{"name":"Fernandes Figueira Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FB","family":"Russomano","sequence":"additional","affiliation":[{"name":"Fernandes Figueira Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"Trist\u00e3o","sequence":"additional","affiliation":[{"name":"Fernandes Figueira Institute Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Huf","sequence":"additional","affiliation":[{"name":"National Institute of Quality Control in Health Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Prendiville","sequence":"additional","affiliation":[{"name":"Walter Prendiville International Agency for Research on Cancer World Health Organization Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Cervical cancer. Estimated incidence mortality and prevalence worldwide in 2012. [http:\/\/globocan.iarc.fr\/old\/FactSheets\/cancers\/cervix-new.asp]. Accessed 21 April 2014."},{"key":"e_1_2_6_3_1","volume-title":"Cancer Incidence in Brazil","year":"2014"},{"key":"e_1_2_6_4_1","first-page":"75","volume-title":"Colposcopy: Management Options","author":"Prendiville W","year":"2003"},{"key":"e_1_2_6_5_1","unstructured":"2011 IFCPC Nomenclature. [www.ifcpc.org\/images\/docs\/nomenclature]. 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