{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:24:30Z","timestamp":1791699870483,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Congenital heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>) is the most common congenital malformation and causes major morbidity and mortality. Prenatal detection improves the neonatal condition before surgery, resulting in less morbidity and mortality. In the Netherlands a national prenatal screening programme was introduced in 2007. This study evaluates the effects of this screening programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Geographical cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Large referral region of three tertiary care centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fetuses and infants diagnosed with severe <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> born between 1 January 2002 and 1 January 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were divided into two groups: before and after the introduction of screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Detection rates were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prenatal detection rate (<jats:italic>n<\/jats:italic>\u00a0=\u00a01912) increased with 23.9% (95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 19.5\u201328.3) from 35.8 to 59.7% after the introduction of screening and of isolated <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> with 21.4% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 16.0\u201326.8) from 22.8 to 44.2%. The highest detection rates were found in the hypoplastic left heart syndrome, other univentricular defects and complex defects with atrial isomerism (&gt;93%). Since the introduction of screening, the \u2018late\u2019 referrals (after 24\u00a0weeks of gestation) decreased by 24.3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 19.3\u201329.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the largest cohort study to investigate the prenatal detection rate of severe <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> in an unselected population. A nationally organised screening has resulted in a remarkably high detection rate of <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> (59.7%) compared with earlier literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13274","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T09:03:52Z","timestamp":1422349432000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":198,"title":["Prenatal detection of congenital heart disease\u2014results of a national screening programme"],"prefix":"10.1111","volume":"123","author":[{"given":"CL","family":"van Velzen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA","family":"Clur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology 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