{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:56:17Z","timestamp":1780610177844,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether differences exist in routine first trimester maternal serum screening analyte measurements between normal pregnancies, placenta praevia and abnormally invasive placentation (<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multidisciplinary audit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Associated university teaching hospital with 9000 annual deliveries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Five hundred and sixteen pregnancies in total, including 344 normal controls, 17 with <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> and 155 placenta praevia cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comparison of maternal serum free \u03b2<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A MoMs distribution in pregnancies with abnormally invasive placentation, placenta praevia and normal controls, after correcting for known confounding factors between October 2005 and September 2013. Data from a previously published first trimester <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> and biochemistry study were combined with our study data and compared in the above way to complete the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Differences in first trimester maternal serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A and free \u03b2<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>, placenta praevia, and normal pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median free \u03b2<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> MoM in the control group was 1.04, and 1.08 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.859) in the placenta praevia group compared with 0.81 in the <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). Median <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A MoM was 1.01 in the control group and 1.05 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.83) in praevia, compared with 1.22 in <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> cases (0.16). The combined <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> dataset gave an overall <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A median MoM of 1.40, and free \u03b2<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> of 0.85. Both markers showed a significantly different distribution from controls (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002 and free \u03b2<jats:styled-content style=\"fixed-case\">hCG <\/jats:styled-content><jats:italic>P<\/jats:italic>\u00a0=\u00a00.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There may be differences between first trimester maternal serum biochemical markers between normal pregnancies and those complicated by abnormally invasive placentation. If upheld, this may provide useful information for the early identification of abnormally invasive placentation. More studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13298","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T09:06:56Z","timestamp":1422868016000},"page":"1370-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["First trimester maternal serum biochemical markers of aneuploidy in pregnancies with abnormally invasive placentation"],"prefix":"10.1111","volume":"122","author":[{"given":"O","family":"Thompson","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Queens Hospital Romford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Otigbah","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Queens Hospital Romford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nnochiri","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Queens Hospital Romford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sumithran","sequence":"additional","affiliation":[{"name":"Department of Pathology Queens Hospital Romford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Spencer","sequence":"additional","affiliation":[{"name":"Prenatal Research Unit Department of Clinical Biochemistry King George Hospital Goodmayes UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12130"},{"key":"e_1_2_6_3_1","first-page":"1","volume-title":"Placenta Praevia, Placenta Praevia Accreta and Vasa Praevia: Diagnosis and Management","author":"Royal College of Obstetricians and Gynaecologists, London","year":"2011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00460-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1926"},{"key":"e_1_2_6_6_1","first-page":"247","volume-title":"Operative Obstetrics: Safer Motherhood. 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