{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:38:59Z","timestamp":1790501939286,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG BI 195\/50"],"award-info":[{"award-number":["DFG BI 195\/50"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KI 1306\/3-1"],"award-info":[{"award-number":["KI 1306\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Tuebingen","award":["E.05.00303"],"award-info":[{"award-number":["E.05.00303"]}]},{"name":"University of Tuebingen","award":["E.05.0259.1"],"award-info":[{"award-number":["E.05.0259.1"]}]},{"DOI":"10.13039\/100008316","name":"Landesstiftung Baden-Wuerttemberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008316","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Fetal magnetoencephalography records fetal brain activity non\u2010invasively. Delayed brain responses were reported for fetuses weighing below the tenth percentile. To investigate whether this delay indicates delayed brain maturation resulting from placental insufficiency, this study distinguished two groups of fetuses below the tenth percentile: growth\u2010restricted fetuses with abnormal umbilical artery Doppler velocity (\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      ) and constitutionally small\u2010for\u2010gestational\u2010age fetuses with normal umbilical artery Doppler findings (\n                      <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\n                      ) were compared with fetuses of adequate weight for gestational age (\n                      <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\n                      ), matched for age and behavioural state.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A case\u2013control study of matched pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Fetal magnetoencephalography\u2010Center at the University Hospital of Tuebingen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>\n                      Fourteen\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      fetuses and 23\n                      <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\n                      fetuses were matched for gestational age and fetal behavioural state with 37 healthy, normal\u2010sized fetuses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 156\u2010channel fetal magentoencephalography system was used to record fetal brain activity. Light flashes as visual stimulation were applied to the fetus. The Student's\n                      <jats:italic>t<\/jats:italic>\n                      <jats:bold>\u2010<\/jats:bold>\n                      test for paired groups was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>Latency of fetal visual evoked magnetic responses (VER).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      fetuses showed delayed\n                      <jats:styled-content style=\"fixed-case\">VER<\/jats:styled-content>\n                      s compared with controls (\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      , 233.1\u00a0ms; controls, 184.6\u00a0ms;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.032).\n                      <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\n                      fetuses had similar evoked response latencies compared with controls (\n                      <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\n                      , 216.1\u00a0ms; controls, 219.9\u00a0ms;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.828). Behavioural states were similarly distributed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Visual evoked responses are delayed in\n                      <jats:styled-content style=\"fixed-case\">IUGR<\/jats:styled-content>\n                      fetuses, but not in\n                      <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>\n                      . Fetal behavioural state as an influencing factor of brain response latency was accounted for in the comparison. This reinforces that delayed brain maturation is the result of placental insufficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.13347","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T18:23:55Z","timestamp":1427999035000},"page":"1184-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Functional brain development in growth\u2010restricted and constitutionally small fetuses: a fetal magnetoencephalography case\u2013control study"],"prefix":"10.1111","volume":"122","author":[{"given":"EC","family":"Morin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"},{"name":"fMEG\u2010Center University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Schleger","sequence":"additional","affiliation":[{"name":"fMEG\u2010Center University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Preissl","sequence":"additional","affiliation":[{"name":"fMEG\u2010Center University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Braendle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"},{"name":"fMEG\u2010Center University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Eswaran","sequence":"additional","affiliation":[{"name":"SARA Research Center Department of Obstetrics and Gynecology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Abele","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"},{"name":"University Women's Hospital and Research Institute for Women's Health Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kiefer\u2010Schmidt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Tuebingen Tuebingen Germany"},{"name":"fMEG\u2010Center University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.06.016"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.10.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00532-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2005.04.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.04.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12025"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.04.035"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.5.450"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1515\/jpm-2013-0022","article-title":"Is there a relationship between fetal brain function and the fetal behavioral state? 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