{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:13:13Z","timestamp":1784905993923,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the nature and conditions of the occurrence of adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s) of bromocriptine, which is used to inhibit lactation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Cases from the French pharmacovigilance database and the marketing authorisation holders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Serious <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s reported between 1994 and 2010 in association with bromocriptine used for lactation inhibition in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each case was checked to confirm the bromocriptine indication, the seriousness of the <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>, the modalities of bromocriptine use, and to identify possible associated predisposing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Number and description of serious <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s, with a particular focus on misuse and associated predisposing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 105 serious <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s, including two fatal cases, the most frequent were cardiovascular (70.5%), neurological (14.3%), and psychiatric (8.6%) disorders. Cardiovascular disorders primarily consisted of ischaemic manifestations (<jats:italic>n<\/jats:italic>\u00a0=\u00a047): acute ischaemic stroke (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, one death), myocardial infarction (<jats:italic>n<\/jats:italic>\u00a0=\u00a011, one death), and reversible postpartum cerebral angiopathy (<jats:italic>n<\/jats:italic>\u00a0=\u00a010). Misuse was identified in 52 cases (70.3%) of cardiovascular disorders, and mostly consisted of bromocriptine continuation despite the occurrence of first symptoms suggesting\u00a0an <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content> or the absence of a progressive titration of bromocriptine. About half of these women had cardiovascular\u00a0predisposing factors, mainly tobacco smoking, overweight or obesity, or a history of hypertension or pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This survey, together with published data, provides further evidence that serious <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s still occur after bromocriptine use in lactation inhibition, and that most of these ADRs could have been avoided. The use of bromocriptine should therefore be limited to cases where no other options are available to inhibit lactation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13352","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T01:54:54Z","timestamp":1426125294000},"page":"1244-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Severe adverse effects of bromocriptine in lactation inhibition: a pharmacovigilance survey"],"prefix":"10.1111","volume":"122","author":[{"given":"N","family":"Bernard","sequence":"first","affiliation":[{"name":"Centre de Pharmacovigilance \u2013 Centre Antipoison Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Jantzem","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance CHU de Brest H\u00f4pital de la Cavale Blanche Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Becker","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance H\u00f4pital Central Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pecriaux","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance Groupe Hospitalier Cochin B\u00e2timent Lavoisier Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"B\u00e9nard\u2010Laribi\u00e8re","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance CHU de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie M\u00e9dicale et Clinique Centre Midi\u2010Pyr\u00e9n\u00e9es de Pharmacovigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament \u00e9quipe de pharmaco\u00e9pid\u00e9miologie UMR INSERM 1027 Facult\u00e9 de M\u00e9decine Centre Hospitalo\u2010universitaire Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Descotes","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance \u2013 Centre Antipoison Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Vial","sequence":"additional","affiliation":[{"name":"Centre de Pharmacovigilance \u2013 Centre Antipoison Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Network of Regional Pharmacovigilance Centres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"12","volume-title":"Pharmacological and Clinical Aspects of Bromocriptine (Parlodel)","author":"Fl\u00fcckiger E","year":"1976"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01872384"},{"key":"e_1_2_6_4_1","first-page":"16","article-title":"\u00c0 propos d'une enqu\u00eate de pharmacovigilance sur la bromocriptine utilis\u00e9e dans l'inhibition de la lactation","volume":"9","author":"Graille V","year":"1995","journal-title":"La Lettre du pharmacologue"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Breastfeeding rates in maternity units and at 1 month. 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