{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:48:13Z","timestamp":1778899693668,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pfizer, formerly Pharmacia","award":["524E-CVD-9101-0001"],"award-info":[{"award-number":["524E-CVD-9101-0001"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Does low\u2010molecular\u2010weight heparin (<jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content>) added to low\u2010dose aspirin influence fetal growth and flow velocity in uterine and umbilical arteries in women with an inheritable thrombophilia and previous early\u2010onset uteroplacental insufficiency?<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary outcomes of the <jats:styled-content style=\"fixed-case\">FRUIT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre, international.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">FRUIT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> included 139 women with inheritable thrombophilia before 12\u00a0weeks of gestation. Inclusion criteria were previous delivery before 34\u00a0weeks of gestation with a hypertensive disorder of pregnancy and\/or small\u2010for\u2010gestational\u2010age infant and an inheritable thrombophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After randomisation to either daily <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content> with aspirin, or aspirin only, ultrasound measurements were performed at 22\u201324, 28\u201330 and 34\u201336\u00a0weeks of gestation. Development during gestation of growth, birthweight and flow velocity of the umbilical artery was examined using the linear mixed model. Uterine artery flow velocity at a single time\u2010point (22\u201324\u00a0weeks) was examined using a chi\u2010square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Fetal growth over time including birthweight, using Scandinavian, Dutch and customised growth curves; and flow velocity within the uterine and umbilical arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No difference of fetal growth over time could be demonstrated between the study arms, regardless of which reference criteria were used. The flow velocity within the uterine artery and umbilical artery did not differ between study arms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content> to aspirin did not influence fetal growth or umbilical artery flow velocity over time; nor did it influence uterine artery flow velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>LMWH does not influence fetal growth or uterine or umbilical flow velocities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13421","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:33:22Z","timestamp":1433378002000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Does low\u2010molecular\u2010weight heparin influence fetal growth or uterine and umbilical arterial Doppler in women with a history of early\u2010onset uteroplacental insufficiency and an inheritable thrombophilia? Secondary randomised controlled trial results"],"prefix":"10.1111","volume":"123","author":[{"given":"CNH","family":"Abheiden","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ME","family":"Van Hoorn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WM","family":"Hague","sequence":"additional","affiliation":[{"name":"Robinson Research Institute University of Adelaide Women's and Children's Hospital North Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PJ","family":"Kostense","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MG","family":"van Pampus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Onze Lieve Vrouwe Gasthuis Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIP","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04553.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-478958"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07830.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(67)80066-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12517"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05020114.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11496.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2009.09.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06030168.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91342-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006440.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3356(21)00411-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01445.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80016-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0395"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(09)60294-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2003.10.013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.02.032"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.9.1099-b"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.1_Spec_No.30"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb12977.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.4_Spec_No.418"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302510"},{"key":"e_1_2_7_27_1","unstructured":"Website to calculate p50 for Gardosi:http:\/\/www.hutchon.net\/CESDIcalc.htm. Accessed August 2011."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.061"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000292457"},{"key":"e_1_2_7_30_1","volume-title":"Linear Mixed Model for Longitudinal Data","author":"Verbeke GMG","year":"2000"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-05-0340"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e9322a"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-391383"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32641-X"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460701730032"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.506566"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00205.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12282"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq411"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00413-8"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13421","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.13421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:25:05Z","timestamp":1696353905000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.13421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/1471-0528.13421"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.13421","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]},"assertion":[{"value":"2015-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}