{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:00:44Z","timestamp":1790078444197,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between duration of rupture of membranes (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>) and mother\u2010to\u2010child <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission (<jats:styled-content style=\"fixed-case\">MTCT<\/jats:styled-content>) rates in the era of combination antiretroviral therapy (<jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The National Study of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> in Pregnancy and Childhood (<jats:styled-content style=\"fixed-case\">NSHPC<\/jats:styled-content>) undertakes comprehensive population\u2010based surveillance of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> in pregnant women and children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> and Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 2398 singleton pregnancies delivered vaginally, or by emergency caesarean section, in women on <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content> in pregnancy during the period 2007\u20132012 with information on duration of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> HIV<\/jats:styled-content> infection status was available for 1898 infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive analysis of <jats:styled-content style=\"fixed-case\">NSHPC<\/jats:styled-content> data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Rates of <jats:styled-content style=\"fixed-case\">MTCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2116 pregnancies delivered at term, the median duration of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> was 3\u00a0hours 30\u00a0minutes (interquartile range, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1\u20138\u00a0hours). The overall <jats:styled-content style=\"fixed-case\">MTCT<\/jats:styled-content> rate for women delivering at term with duration of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> \u22654\u00a0hours was 0.64% compared with 0.34% for <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> &lt;4\u00a0hours, with no significant difference between the groups (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a01.90, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.45\u20137.97). In women delivering at term with a viral load of &lt;50\u00a0copies\/ml, there was no evidence of a difference in <jats:styled-content style=\"fixed-case\">MTCT<\/jats:styled-content> rates with duration of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> \u22654\u00a0hours, compared with &lt;4\u00a0hours (0.14% for \u22654\u00a0hours versus 0.12% for &lt;4\u00a0hour; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a01.14, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.07\u201318.27). Among infants born preterm with infection status available, there were no transmissions in 163 deliveries where the maternal viral load was &lt;50\u00a0copies\/ml.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No association was found between duration of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MTCT<\/jats:styled-content> in women taking <jats:styled-content style=\"fixed-case\">cART<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Rupture of membranes of more than 4 hours is not associated with MTCT of HIV in women on effective ART delivering at term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13442","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T08:18:37Z","timestamp":1432282717000},"page":"975-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Duration of ruptured membranes and mother\u2010to\u2010child <scp>HIV<\/scp> transmission: a prospective population\u2010based surveillance study"],"prefix":"10.1111","volume":"123","author":[{"given":"H","family":"Peters","sequence":"first","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Byrne","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"De Ruiter","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Francis","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Harding","sequence":"additional","affiliation":[{"name":"Guys &amp; St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GP","family":"Taylor","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PA","family":"Tookey","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CL","family":"Townsend","sequence":"additional","affiliation":[{"name":"Population, Policy and Practice Programme UCL Institute of Child Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000212"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08084-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401301"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2012.01030.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90286-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606203342501"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/00002030-199612000-00012","article-title":"Vertical transmission of HIV\u20101: maternal immune status and obstetric factors. 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