{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:40:46Z","timestamp":1788475246994,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007870","name":"Department of Obstetrics and Gynecology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8UL1TR000105"],"award-info":[{"award-number":["8UL1TR000105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR025764"],"award-info":[{"award-number":["UL1RR025764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the neuroprotective effect of magnesium sulfate (Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>) in preterm children exposed to chorioamnionitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A secondary analysis of a multicentre randomised controlled trial of antenatal Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> administered to women at risk of preterm birth for the prevention of cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>). Singleton, non\u2010anomalous pregnancies with clinical chorioamnionitis, delivering at \u226524\u00a0weeks of gestation, were selected. Cases were exposed to antepartum Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>; controls received placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Multicentre randomised controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Singleton, non\u2010anomalous pregnancies with clinical chorioamnionitis, delivering at \u226524\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All data were analysed by intention to treat. Univariate and multivariate analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Primary outcome was a composite of stillbirth, death by the age of 1\u00a0year, or moderate or severe <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> by the age of 2\u00a0years. Secondary outcomes included a composite neonatal outcome as well as neurodevelopmental delay, defined as Bayley II mental and psychomotor developmental indices &lt;70 at the age of 2\u00a0years. Subgroup analysis assessed these outcomes in children born at &lt;28\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 396 children were included, with 192 (48.5%) randomised to Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub>. Maternal and delivery characteristics were similar between the groups. The primary outcome occurred in 14.1% of children exposed to Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> and 12.7% of children exposed to placebo (relative risk, <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.29; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.70\u20132.38). Rates of stillbirth, death, moderate\u2013severe <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, and neurodevelopmental delay did not differ between groups. In the subgroup analysis of children born at &lt;28\u00a0weeks of gestation, there was no difference in the rates of the primary outcome, nor in the secondary outcomes assessed. [Correction added on 02 March 2016 after online publication: There were errors in statistical data analysis and these have been corrected throughout the article.]<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among children at risk for early preterm delivery exposed to chorioamnionitis, antenatal administration of Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> was not associated with improved neurodevelopmental outcome. We do not recommend any change in the guidelines on the administration of Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> for neuroprotection based on this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Mg<jats:styled-content style=\"fixed-case\">SO<\/jats:styled-content><jats:sub>4<\/jats:sub> was not associated with improved neurodevelopmental outcome in setting of chorioamnionitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13460","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:33:17Z","timestamp":1433377997000},"page":"1161-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Magnesium sulfate, chorioamnionitis, and neurodevelopment after preterm birth"],"prefix":"10.1111","volume":"123","author":[{"given":"M","family":"Kamyar","sequence":"first","affiliation":[{"name":"Division of Maternal\u2013Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TA","family":"Manuck","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2013Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GJ","family":"Stoddard","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Department of Internal Medicine University of Utah School of Medicine Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MW","family":"Varner","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2013Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EAS","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2013Fetal Medicine Department of Obstetrics and Gynecology University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181870994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2008.07.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338066"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.11.1417"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70432-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104207"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e90046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2669"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a60495"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2007.04.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801187"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181ae98c2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.06.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101765"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12118"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh221"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi188"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280210395740"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.13460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1471-0528.13460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.13460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:07:45Z","timestamp":1694750865000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.13460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/1471-0528.13460"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.13460","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]},"assertion":[{"value":"2015-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}