{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:15Z","timestamp":1787013675085,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["30505"],"award-info":[{"award-number":["30505"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To estimate health benefits and incremental cost\u2010effectiveness of human papillomavirus (\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      ) vaccination of pre\u2010adolescent boys and girls compared with girls alone for preventing cervical cancer and genital warts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Model\u2010based economic evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Southern Vietnam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Males and females aged \u22659\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We simulated dynamic\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      transmission to estimate cervical cancer and genital warts cases. Models were calibrated to epidemiological data from south Vietnam.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>\n                      Incremental cost\u2010effectiveness ratios (\n                      <jats:styled-content style=\"fixed-case\">ICER<\/jats:styled-content>\n                      s): cost per quality\u2010adjusted life\u2010year (\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vaccinating girls alone was associated with reductions in lifetime cervical cancer risk ranging from 20 to 56.9% as coverage varied from 25 to 90%. Adding boys to the vaccination programme yielded marginal incremental benefits (\u22643.6% higher absolute cervical cancer risk reduction), compared with vaccinating girls alone at all coverages. At \u226425 international dollars (I$) per vaccinated adolescent (I$5 per dose),\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      vaccination of boys was below the threshold of Vietnam's per\u2010capita\n                      <jats:styled-content style=\"fixed-case\">GDP<\/jats:styled-content>\n                      (I$2800), with\n                      <jats:styled-content style=\"fixed-case\">ICER<\/jats:styled-content>\n                      s ranging from I$734 per\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      at 25% coverage to I$2064 per\n                      <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>\n                      for 90% coverage. Including health benefits from averting genital warts yielded more favourable\n                      <jats:styled-content style=\"fixed-case\">ICER<\/jats:styled-content>\n                      s, and vaccination of boys at I$10\/dose became cost\u2010effective at or below 75% coverage. Using a lower cost\u2010effectiveness threshold of 50% of Vietnam's\n                      <jats:styled-content style=\"fixed-case\">GDP<\/jats:styled-content>\n                      (I$1400), vaccinating boys was no longer attractive at costs above I$5 per dose regardless of coverage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vaccination of boys may be cost\u2010effective at low vaccine costs, but provides little benefit over vaccinating girls only. Focusing on achieving high vaccine coverage of girls may be more efficient for southern Vietnam and similar low\u2010resource settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>\n                      Limited cervical cancer reduction from including boys in\n                      <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                      vaccination of girls in low\u2010resource settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.13503","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T05:35:21Z","timestamp":1436938521000},"page":"917-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The value of male human papillomavirus vaccination in preventing cervical cancer and genital warts in a low\u2010resource setting"],"prefix":"10.1111","volume":"123","author":[{"given":"M","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sy","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management Center for Health Decision Science Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management Center for Health Decision Science Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Globocan Country Fact Sheet: Viet Nam. [http:\/\/globocan.iarc.fr\/factsheets\/populations\/factsheet.asp?uno=704]. Accessed 5 May 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1363\/3216606"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20164"},{"key":"e_1_2_7_5_1","unstructured":"Family Health International.Behind the pleasure: sexual decision\u2010making among high\u2010risk men in urban Vietnam.2006. 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