{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:35:44Z","timestamp":1791246944370,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Science and Technology of the Federal District in Mexico (ICyTDF)","award":["PICDS08-16"],"award-info":[{"award-number":["PICDS08-16"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the usefulness of serial determinations of asymmetric dimethylarginine (<jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>) and homocysteine (Hcy) concentrations during pregnancy to predict pre\u2010eclampsia, taking into account maternal obesity and B\u00a0vitamin status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two obstetric referral hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sample<\/jats:title><jats:p>Two hundred and fifty\u2010two of 411 women invited to participate in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The women made monthly visits from \u226420\u00a0weeks of gestation until delivery for measurements of plasma <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>, Hcy, and vitamins B<jats:sub>6<\/jats:sub>, B<jats:sub>12,<\/jats:sub> and folic acid, and for the recording of clinical information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measure<\/jats:title><jats:p>Early elevations in plasma <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and Hcy related to the development of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 252 women who completed the study, 179 had no complications, 49 developed pre\u2010eclampsia, and 24 presented with complications other than pre\u2010eclampsia. <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and Hcy increased gradually throughout pregnancy in the pre\u2010eclampsia group, independent of maternal B\u2013vitamin status and obesity, but remained constant in women with no complications. Relative to the preceding month, <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and Hcy levels increased 1\u00a0month prior to the onset of pre\u2010eclampsia: 124\u00a0\u00b1\u00a027\u00a0nmol (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and 1177\u00a0\u00b1\u00a0278\u00a0nmol (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001), respectively, in the pre\u2010eclampsia group. The group of women with no complications did not show any significant changes. Increases of 80\u00a0nmol <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and 1000\u00a0nmol Hcy at 1\u00a0month prior to the onset of pre\u2010eclampsia demonstrated the best potential for prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and Hcy levels precede clinical manifestations of pre\u2010eclampsia. Therefore, serial determinations of their concentrations may be helpful in identifying women at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Increased <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and Hcy precede clinical pre\u2010eclampsia and may identify women at risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13516","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:47:10Z","timestamp":1437785230000},"page":"1586-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre\u2010eclampsia: a longitudinal study"],"prefix":"10.1111","volume":"122","author":[{"given":"M","family":"L\u00f3pez\u2010Alarc\u00f3n","sequence":"first","affiliation":[{"name":"Unit of Research in Medical Nutrition Centro M\u00e9dico Nacional Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Montalvo\u2010Velarde","sequence":"additional","affiliation":[{"name":"Unit of Research in Medical Nutrition Centro M\u00e9dico Nacional Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VS","family":"Vital\u2010Reyes","sequence":"additional","affiliation":[{"name":"Hospital of Obstetrics and Gynaecology #3 Centro M\u00e9dico La Raza Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JC","family":"Hinojosa\u2010Cruz","sequence":"additional","affiliation":[{"name":"Hospital of Obstetrics and Gynaecology #3 Centro M\u00e9dico La Raza Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lea\u00f1os\u2010Miranda","sequence":"additional","affiliation":[{"name":"Hospital of Obstetrics and Gynaecology #4 Luis Castelazo Ayala Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mart\u00ednez\u2010Basila","sequence":"additional","affiliation":[{"name":"Unit of Research in Medical Nutrition Centro M\u00e9dico Nacional Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000249609.04831.7c"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055352"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032011001100008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.820"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328357c0c9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182571669"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.169094"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03311.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.198"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13177-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.05.052"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00543-X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2010.10.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5083235"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(03)00035-7"},{"key":"e_1_2_6_18_1","unstructured":"The American College of Obstetrics and Gynecology.The Task Force on Hypertension in Pregnancy. 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