{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:46:13Z","timestamp":1782773173021,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MCT 87522"],"award-info":[{"award-number":["MCT 87522"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether the difference in outcomes between \u2018less tight\u2019 (target diastolic blood pressure [<jats:styled-content style=\"fixed-case\">dBP<\/jats:styled-content>] of 100\u00a0mmHg) versus \u2018tight\u2019 control (target <jats:styled-content style=\"fixed-case\">dBP<\/jats:styled-content> of 85\u00a0mmHg) in the <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content> Trial (<jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content> 71416914, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/pre-empt.cfri.ca\/\">http:\/\/pre-empt.cfri.ca\/<\/jats:ext-link>;<jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content>) depended on the choice of labetalol or methyldopa, the two most commonly used antihypertensive agents in <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content> Trial data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>International multicentre randomised controlled trial (94 sites, 15 countries).<\/jats:p><\/jats:sec><jats:sec><jats:title>Population or sample<\/jats:title><jats:p>A total of 987 women with non\u2010severe non\u2010proteinuric pregnancy hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Logistic regression was used for comparisons of \u2018less tight\u2019 versus \u2018tight\u2019 control among women treated with labetalol (but not methydopa) versus methyldopa (but not labetalol). Analyses were adjusted for the influence of baseline factors, including use of any antihypertensive therapy at randomisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Main <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content> Trial outcomes: primary (perinatal loss or high\u2010level neonatal care for &gt;\u00a048\u00a0hours), secondary (serious maternal complications), birthweight &lt;\u00a010th centile, severe maternal hypertension, pre\u2010eclampsia, and delivery at &lt;\u00a034 or &lt;\u00a037\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 987 women in <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content>, antihypertensive therapy was taken by 566 women at randomisation (labetalol 111 [\u2018less tight\u2019] versus 127 [\u2018tight\u2019] or methyldopa 126 [\u2018less tight\u2019] versus 117 [\u2018tight\u2019]) and 815 women after randomisation (labetalol 186 [\u2018less tight\u2019] versus 247 [\u2018tight\u2019] and methyldopa by 98 [\u2018less tight\u2019] versus 126 [\u2018tight\u2019]). Following adjustment, odds ratios for outcomes in \u2018less tight\u2019 versus \u2018tight\u2019 control were similar between antihypertensive groups according to \u2018at randomisation\u2019 and \u2018after randomisation\u2019 therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcomes for \u2018less tight\u2019 versus \u2018tight\u2019 control were not dependent on use of methyldopa or labetalol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">CHIPS<\/jats:styled-content> Trial, maternal and infant outcomes were not dependent on use of labetalol or methyldopa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13568","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T06:56:59Z","timestamp":1439276219000},"page":"1135-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Control of Hypertension In Pregnancy Study randomised controlled trial\u2014are the results dependent on the choice of labetalol or methyldopa?"],"prefix":"10.1111","volume":"123","author":[{"given":"LA","family":"Magee","sequence":"first","affiliation":[{"name":"Medicine University of British Columbia Vancouver BC Canada"},{"name":"Obstetrics and Gynaecology University of British Columbia Vancouver BC Canada"},{"name":"School of Population and Public Health University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CHIPS Study 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Toronto ON Canada"},{"name":"The Centre for Mother Infant and Child Research Sunnybrook Research Institute University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Menzies","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sanchez","sequence":"additional","affiliation":[{"name":"The Centre for Mother Infant and Child Research Sunnybrook Research Institute University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gafni","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Gruslin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University of 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