{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:32:23Z","timestamp":1789979543224,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003180","name":"Academisch Medisch Centrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["2100.0076"],"award-info":[{"award-number":["2100.0076"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether maternal vitamin B<jats:sub>12<\/jats:sub>and folate status during early pregnancy are associated with cardiometabolic risk factors in the offspring at age 5\u20136.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective multi\u2010ethnic birth cohort, the Amsterdam Born Children and their Development study (ABCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>12\u00a0373 pregnant women living in Amsterdam were approached between 2003 and 2004 for participation in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Mother\u2013child pairs for whom information on maternal vitamin B<jats:sub>12<\/jats:sub>or folate status in early gestation and health at age 5\u20136\u00a0years was available (<jats:italic>n<\/jats:italic>\u00a0=\u00a01950).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vitamin B<jats:sub>12<\/jats:sub>and folate concentrations were determined in maternal serum at intake in early pregnancy (median 13\u00a0weeks' gestation). Anthropometric measurements, blood pressure and fasting blood samples were collected during a health check of children aged 5\u20136\u00a0years. Multiple linear regression was performed to investigate the association between maternal serum concentrations and children's outcomes, corrected for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Gestational age at birth, birthweight, body mass index (BMI), glucose levels, triglyceride levels, blood pressure and heart rate of the offspring at age 5\u20136.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low maternal folate levels during early pregnancy were associated with slightly higher BMI in the offspring [decrease per 10 units: \u03b2 0.07\u00a0kg\/m<jats:sup>2<\/jats:sup>, 95% confidence interval (CI) 0.01, 0.13]. Low maternal vitamin B<jats:sub>12<\/jats:sub>concentrations were associated with higher heart rates (decrease per 100 units: \u03b2 0.49 beats\/min, 95% CI 0.11, 0.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides further evidence that maternal nutrition in early pregnancy may possibly program cardiometabolic health of the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Low folate and vitamin B<jats:sub>12<\/jats:sub>levels during pregnancy are associated with higher BMI and heart rate in offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13574","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T14:03:59Z","timestamp":1440511439000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Vitamin B<sub>12<\/sub>and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5\u20136\u00a0years: findings from the<scp>ABCD<\/scp>multi\u2010ethnic birth cohort"],"prefix":"10.1111","volume":"123","author":[{"given":"GG","family":"Krikke","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics Academic Medical Centre Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IJ","family":"Grooten","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics Academic Medical Centre Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TGM","family":"Vrijkotte","sequence":"additional","affiliation":[{"name":"Department of Public Health Academic 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