{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:07:47Z","timestamp":1768892867528,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate long\u2010term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting and Population<\/jats:title><jats:p>Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two years after the <jats:styled-content style=\"fixed-case\">APOSTEL II<\/jats:styled-content> trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Infant development was measured in five domains. Developmental delay was defined as a score of \u22641 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> in one or more developmental domains. We performed exploratory subgroup analysis in women with preterm prolonged rupture of the membranes, and in women with a cervical length &lt;10\u00a0mm at study entry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2\u00a0years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.29\u20139.14, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.01), and a lower incidence of poor problem\u2010solving (21.1 versus 29.1%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.27, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.08\u20100.95, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This follow\u2010up study revealed no clear benefit of nifedipine maintenance tocolysis at 2\u00a0years of age. As short\u2010term adverse perinatal outcome was not reduced in the original <jats:styled-content style=\"fixed-case\">APOSTEL II<\/jats:styled-content> trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>No clear benefit of nifedipine maintenance tocolysis in preterm labour on 2\u2010year infant outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13586","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T12:09:01Z","timestamp":1441195741000},"page":"1107-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Maintenance tocolysis with nifedipine in threatened preterm labour: 2\u2010year follow up of the offspring in the <scp>APOSTEL II<\/scp> trial"],"prefix":"10.1111","volume":"123","author":[{"given":"EOG","family":"van 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