{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:05:38Z","timestamp":1773299138298,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID 1041918"],"award-info":[{"award-number":["ID 1041918"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the association between antidepressant use in late gestation and postpartum haemorrhage (\n PPH<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Tertiary teaching hospital in Adelaide, Australia.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n A total of 30\u00a0198 women delivering between 2002 and 2008.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Relative risks adjusted for maternal sociodemographics and comorbidities (\n aRR<\/jats:styled-content>\n s) were calculated for\n PPH<\/jats:styled-content>\n , comparing women with late\u2010gestation exposure to antidepressants (\n n<\/jats:italic>\n \u00a0=\u00a0558), women with a psychiatric illness but no antidepressant use (\n n<\/jats:italic>\n \u00a0=\u00a01292), and women with neither antenatal exposures (\n n<\/jats:italic>\n \u00a0=\u00a028\u00a0348). Additional sensitivity analyses were undertaken, examining associations with severe\n PPH<\/jats:styled-content>\n and postpartum anaemia.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n \n The primary outcome was\n PPH<\/jats:styled-content>\n , defined as a recorded blood loss of \u2265500\u00a0\n mL<\/jats:styled-content>\n for vaginal deliveries and \u22651000\u00a0\n mL<\/jats:styled-content>\n for caesarean sections. Secondary outcomes included severe\n PPH<\/jats:styled-content>\n (\u22651000\u00a0\n mL<\/jats:styled-content>\n blood loss, irrespective of method of delivery), and the presence of postpartum anaemia (identified from hospital medical records).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with unexposed controls, women exposed to antidepressants had an increased risk of\n PPH<\/jats:styled-content>\n (\n aRR<\/jats:styled-content>\n \u00a01.53; 95% confidence interval, 95%\u00a0\n CI<\/jats:styled-content>\n 1.25\u20131.86), whereas no increased risk was observed for women with a psychiatric illness but no antidepressant use (\n aRR<\/jats:styled-content>\n \u00a01.04; 95%\u00a0\n CI<\/jats:styled-content>\n 0.89\u20131.23). In sensitivity analyses, late gestation antidepressant exposure was associated with an increased risk of severe\n PPH<\/jats:styled-content>\n (\n aRR<\/jats:styled-content>\n \u00a01.84; 95%\u00a0\n CI<\/jats:styled-content>\n 1.39\u20132.44), as well as postpartum anaemia (\n aRR<\/jats:styled-content>\n \u00a01.80; 95%\u00a0\n CI<\/jats:styled-content>\n \u00a01.46\u20132.22).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Exposure to antidepressants in late gestation was associated with a significantly increased risk of\n PPH<\/jats:styled-content>\n . Although potential confounding by unmeasured factors cannot be ruled out, these findings suggest a direct effect of antidepressant exposure on\n PPH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n Late gestation antidepressant exposure is associated with a significantly increased risk of postpartum haemorrhage.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.13612","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:19:21Z","timestamp":1442362761000},"page":"1929-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Antidepressant use in late gestation and risk of postpartum haemorrhage: a retrospective cohort study"],"prefix":"10.1111","volume":"123","author":[{"given":"LE","family":"Grzeskowiak","sequence":"first","affiliation":[{"name":"School of Paediatrics and Reproductive Health The Robinson Research Institute The 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