{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:38:26Z","timestamp":1790735906726,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T00:00:00Z","timestamp":1443052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the relationship of interpregnancy interval with maternal and offspring outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study with data from the Perinatal Information System database of the Latin American Centre for Perinatology and Human Development, Uruguay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Latin America, 1990\u20132009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A cohort of 894 476 women delivering singleton infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During 1990\u20132009 the Perinatal Information System database of the Latin American Centre for Perinatology identified 894 476 women with defined interpregnancy intervals: i.e. the time elapsed between the date of the previous delivery and the first day of the last normal menstrual period for the index pregnancy. Using the interval 12\u201323 months as the reference category, multiple logistic regression estimated adjusted odds ratios (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>s) with 95% confidence intervals (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) of the association between various interval lengths and maternal and offspring outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Maternal death, pre\u2010eclampsia, eclampsia, puerperal infection, fetal death, neonatal death, preterm birth, and low birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the reference interval there was 0.05% maternal death, 1.00% postpartum haemorrhage, 2.80% pre\u2010eclampsia, 0.15% eclampsia, 0.28% puerperal infection, 3.45% fetal death, 0.68% neonatal death, 12.33% preterm birth, and 9.73% low birthweight. Longer intervals had increased odds of pre\u2010eclampsia (&gt;72 months), fetal death (&gt;108\u2013119 months), and low birthweight (96\u2013107 months). Short intervals of &lt;12 months had increased odds of pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 0.80; 95% CI 0.76\u20130.85), neonatal death (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 1.18; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08\u20131.28), and preterm birth (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 1.16; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.11\u20131.21). Statistically, the interval had no relationship with maternal death, eclampsia, and puerperal infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A short interpregnancy interval of &lt;12 months is associated with pre\u2010eclampsia, neonatal mortality, and preterm birth, but not with other maternal or offspring outcomes. Longer intervals of &gt;72 months are associated with pre\u2010eclampsia, fetal death, and low birthweight, but not with other maternal or offspring outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A short interpregnancy interval of &lt;12 months is associated with neonatal mortality and preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13625","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T09:17:02Z","timestamp":1443086222000},"page":"730-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Interpregnancy interval and perinatal outcomes across Latin America from 1990 to 2009: a large multi\u2010country study"],"prefix":"10.1111","volume":"123","author":[{"given":"LE","family":"Mignini","sequence":"first","affiliation":[{"name":"Centro Rosarino de Estudios Perinatales (CREP) Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Carroli","sequence":"additional","affiliation":[{"name":"Centro Rosarino de Estudios Perinatales (CREP) Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AP","family":"Betran","sequence":"additional","affiliation":[{"name":"UNDP\/UNFPA\/WHO\/World Bank Special Programme of Research Development and Training in Human Reproduction (HRP) Department of Reproductive Health and Research World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Fescina","sequence":"additional","affiliation":[{"name":"Centro Latinoamericano de Perinatolog\u00eda (CLAP) Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Cuesta","sequence":"additional","affiliation":[{"name":"Centro Rosarino de Estudios Perinatales (CREP) Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Campodonico","sequence":"additional","affiliation":[{"name":"Centro Rosarino de Estudios Perinatales (CREP) Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"De Mucio","sequence":"additional","affiliation":[{"name":"Centro Latinoamericano de Perinatolog\u00eda (CLAP) Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Khan","sequence":"additional","affiliation":[{"name":"Women's Health Research Unit Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0032472042000213695"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10680-012-9277-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006145610780"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.15.1809"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.055"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a7f63e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4333"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-3-199302010-00009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1728-4465.2012.00308.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.58.110405.085530"},{"key":"e_1_2_7_15_1","volume-title":"Applied Missing Data Analysis","author":"Enders CK","year":"2010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.01.010403"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4358-3-16"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60478-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1998.770407.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07105-7"}],"updated-by":[{"DOI":"10.1111\/1471-0528.14191","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000}}],"container-title":["BJOG: An International Journal of Obstetrics &amp; 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