{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:40:31Z","timestamp":1783068031099,"version":"3.54.6"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Objective<\/jats:title>To determine how well antenatal corticosteroids (ACS<\/jats:styled-content>) were timed, based on the indication for administration for women delivering preterm.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective cohort study.<\/jats:p><\/jats:sec>Setting<\/jats:title>Tertiary medical centre.<\/jats:p><\/jats:sec>Population<\/jats:title>Six hundred and thirty women who had singleton preterm births between 24 and 34\u00a0weeks\u2019 gestational age.<\/jats:p><\/jats:sec>Methods<\/jats:title>Charts from 2006 to 2011 were reviewed for indications for ACS<\/jats:styled-content> administration, which included premature rupture of membranes, threatened preterm labour, risk factors for spontaneous preterm birth such as short ultrasound cervical length, positive fetal fibronectin, and hypertensive disorders of pregnancy. Charts were reviewed for timing of ACS<\/jats:styled-content> administration in relation to delivery.<\/jats:p><\/jats:sec>Main outcome measures<\/jats:title>The primary outcome was optimal timing, defined as administration of ACS<\/jats:styled-content> \u226524\u00a0hours to \u22647\u00a0days prior to delivery.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 630 women who delivered preterm, 589 (93%) received ACS<\/jats:styled-content> prior to delivery. ACS<\/jats:styled-content> timing was optimal in 40% (238 of 589) of cases. Women with hypertensive disorders were most likely to have steroids optimally timed (62%). Asymptomatic women at increased risk for preterm delivery were less likely to receive optimally timed ACS<\/jats:styled-content> (12%). The majority of women who received steroids >2\u00a0weeks prior to delivery (57%) received a second course.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A majority of women who delivered preterm did not receive optimally timed ACS<\/jats:styled-content>. Diagnostic tools that identified women at risk for preterm birth were not able to identify patients for appropriate steroid timing. Given the range of clinical scenarios in which patients are at increased risk for preterm delivery, further research is needed to assist clinicians in optimising steroid administration.<\/jats:p><\/jats:sec>Tweetable abstract<\/jats:title>Optimal timing of antenatal steroids prior to delivery does not occur in most cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13730","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T17:29:36Z","timestamp":1445362176000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Clinical indication and timing of antenatal corticosteroid administration at a single centre"],"prefix":"10.1111","volume":"123","author":[{"given":"HI","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CV","family":"Ananth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"},{"name":"Department of Epidemiology Joseph L. Mailman School of Public Health Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Benjamin\u2010Boamah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Siddiq","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AM","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts D","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90223-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.50.4.515"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"12","year":"1994","journal-title":"NIH Consens Statement"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.12.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.050"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2608"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802559095"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000629"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.021"},{"issue":"6","key":"e_1_2_7_13_1","first-page":"CD003935","article-title":"Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes","author":"Crowther CA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.09.024"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.962508"}],"container-title":["BJOG: An International Journal of Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13730","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.13730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:40:45Z","timestamp":1696308045000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.13730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/1471-0528.13730"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.13730","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]},"assertion":[{"value":"2015-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}