{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:25:48Z","timestamp":1788269148495,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["80\u201082310\u201098\u201009056"],"award-info":[{"award-number":["80\u201082310\u201098\u201009056"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Objective<\/jats:title>\n \n To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (\n fFN<\/jats:styled-content>\n ) testing and cervical length (\n CL<\/jats:styled-content>\n ) improves the prediction of preterm delivery (\n PTD<\/jats:styled-content>\n ) within 7\u00a0days compared with qualitative\n fFN<\/jats:styled-content>\n and CL.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Post hoc<\/jats:italic>\n analysis of frozen\n fFN<\/jats:styled-content>\n samples of a nationwide cohort study.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Ten perinatal centres in the Netherlands.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Symptomatic women between 24 and 34\u00a0weeks of gestation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The risk of\n PTD<\/jats:styled-content>\n \u00a0<7\u00a0days was estimated in predefined\n CL<\/jats:styled-content>\n and\n fFN<\/jats:styled-content>\n strata. We used logistic regression to develop a model including quantitative\n fFN<\/jats:styled-content>\n and\n CL<\/jats:styled-content>\n , and one including qualitative\n fFN<\/jats:styled-content>\n (threshold 50\u00a0ng\/ml) and\n CL<\/jats:styled-content>\n . We compared the models\u2019 capacity to identify women at low risk (<5%) for delivery within 7\u00a0days using a reclassification table.\n <\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Spontaneous delivery within 7\u00a0days after study entry.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We studied 350 women, of whom 69 (20%) delivered within 7\u00a0days. The risk of\n PTD<\/jats:styled-content>\n in <7\u00a0days ranged from 2% in the lowest\n fFN<\/jats:styled-content>\n group (<10\u00a0ng\/ml) to 71% in the highest group (>500\u00a0ng\/ml). Multivariable logistic regression showed an increasing risk of\n PTD<\/jats:styled-content>\n in <7\u00a0days with rising\n fFN<\/jats:styled-content>\n concentration [10\u201349\u00a0ng\/ml: odds ratio (\n OR<\/jats:styled-content>\n ) 1.3, 95% confidence interval (95%\n CI<\/jats:styled-content>\n ) 0.23\u20137.0; 50\u2013199\u00a0ng\/ml:\n OR<\/jats:styled-content>\n 3.2, 95%\n CI<\/jats:styled-content>\n 0.79\u201313; 200\u2013499\u00a0ng\/ml:\n OR<\/jats:styled-content>\n 9.0, 95%\n CI<\/jats:styled-content>\n 2.3\u201335; >500\u00a0ng\/ml:\n OR<\/jats:styled-content>\n 39, 95%\n CI<\/jats:styled-content>\n 9.4\u2013164] and shortening of the\n CL<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 0.86 per mm, 95%\n CI<\/jats:styled-content>\n 0.82\u20130.90). Use of quantitative\n fFN<\/jats:styled-content>\n instead of qualitative\n fFN<\/jats:styled-content>\n resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7\u00a0days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In symptomatic women, quantitative\n fFN<\/jats:styled-content>\n testing does not improve the prediction of\n PTD<\/jats:styled-content>\n within 7\u00a0days compared with qualitative\n fFN<\/jats:styled-content>\n testing in combination with\n CL<\/jats:styled-content>\n measurement in terms of reclassification from high to low (<5%) risk, but it adds value across the risk range.\n <\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n Quantitative fFN testing adds value to qualitative fFN testing with CL measurement in the prediction of PTD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.13752","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T03:21:13Z","timestamp":1450149673000},"page":"1965-1971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women"],"prefix":"10.1111","volume":"123","author":[{"given":"MMC","family":"Bruijn","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JY","family":"Vis","sequence":"additional","affiliation":[{"name":"Clinical Chemistry and Haematology University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FF","family":"Wilms","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Oudijk","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kwee","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University Medical Centre Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MM","family":"Porath","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology M\u00e1xima Medical Centre Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Oei","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology M\u00e1xima Medical Centre Veldhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HCJ","family":"Scheepers","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University Hospital Maastricht Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEA","family":"Spaanderman","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University Hospital Maastricht Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KWM","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Obstetrics Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"Haak","sequence":"additional","affiliation":[{"name":"Obstetrics Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Bolte","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FPHA","family":"Vandenbussche","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Woiski","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CJ","family":"Bax","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JMJ","family":"Cornette","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Erasmus Medical Centre Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ","family":"Duvekot","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Erasmus Medical Centre Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BWA","family":"Nij Bijvanck","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Isala Clinics Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van Eyck","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Isala Clinics Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MTM","family":"Franssen","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Sollie","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAM","family":"van der Post","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PMM","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology, Biostatistics and Bioinformatics Academic Medical 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Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide","volume":"263","author":"Matsuura H","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.12.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000229"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.10.890"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-38"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.01.018"},{"key":"e_1_2_7_12_1","volume-title":"Threatened Preterm Labour. 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