{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:15Z","timestamp":1787013675072,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate relapse rates after the successful treatment of patients with non\u2010atypical endometrial hyperplasia who were randomised to either a levonorgestrel\u2010impregnated intrauterine system (LNG\u2010IUS; Mirena\n \u00ae<\/jats:sup>\n ) or two regimens of oral medroxyprogesterone acetate (MPA) after primary histological response.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A multicentre randomised trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Ten different outpatient clinics localised in hospitals and seven gynaecological private practices in Norway.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n One hundred and fifty\u2010three women aged 30\u201370 years with low\u2010 or medium\u2010risk endometrial hyperplasia met the inclusion criteria, and 153 completed the therapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients were randomly assigned to one of the following three treatment arms: LNG\u2010IUS; 10 mg of oral MPA administered for 10 days per cycle for 6 months; or 10 mg of oral MPA administered daily for 6 months. The women were followed for 24 months after ending therapy.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n Histological relapse of endometrial hyperplasia.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Histological relapse was observed in 55\/135 (41%) women who had an initial complete treatment response. The relapse rates were similar in the three therapy groups (\n P<\/jats:italic>\n = 0.66). In the multivariable analyses relapse was dependent on menopausal status (\n P<\/jats:italic>\n = 0.0005) and estrogen level (\n P<\/jats:italic>\n = 0.0007).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The risk of histological relapse of non\u2010atypical endometrial hyperplasia is high within 24 months of ceasing therapy with either the LNG\u2010IUS or oral MPA. Continued endometrial surveillance and prolonging progestogen therapy should be considered.<\/jats:p>\n <\/jats:sec>\n \n Tweetable abstract<\/jats:title>\n Relapse of endometrial hyperplasia after successful treatment is independent of therapy regime.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1471-0528.13763","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T08:57:09Z","timestamp":1449046629000},"page":"1512-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Relapse risk of endometrial hyperplasia after treatment with the levonorgestrel\u2010impregnated intrauterine system or oral progestogens"],"prefix":"10.1111","volume":"123","author":[{"given":"A","family":"\u00d8rbo","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology University Hospital of Troms\u00f8 Troms\u00f8 Norway"},{"name":"Research Group for Gynaecologic Oncology Department of Medical Biology Faculty of Health Sciences University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Arnes","sequence":"additional","affiliation":[{"name":"Research Group for Gynaecologic Oncology Department of Medical Biology Faculty of Health Sciences University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AB","family":"Vereide","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Clinic for Surgery, Cancer and Women's Disease University Hospital of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Straume","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Faculty of Health Sciences University of Troms\u00f8 Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850715)56:2<403::AID-CNCR2820560233>3.0.CO;2-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.07.037"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det320"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.07.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.06.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2013.24.2.128"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12499"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90103-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828cb563"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.12.037"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20108\u201018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/EdBook_AM.2013.33.e222"}],"container-title":["BJOG: 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