{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:07:08Z","timestamp":1772766428652,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether women who undergo <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) treatment are at greater risk of postnatal suicide or postnatal depression (<jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>) requiring psychiatric care, compared with women who conceive spontaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study using data from national registers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sweden during the period 2003\u20132009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Cases were 3532 primiparous women who had given birth following <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> treatment. An aged\u2010matched control group of 8553 mothers was randomly selected from the medical birth register.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Logistic regression analyses were performed with <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content> as the outcome, and with known risk factors of <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content> as well as <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/spontaneous birth as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Postnatal depression (<jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>), defined as diagnoses F32\u2013F39 of the tenth edition of the International Classification of Diseases (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201310), within 12 months of childbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial analyses showed that <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content> was more common in the control group than in the <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> group (0.8 versus 0.4%; <jats:italic>P<\/jats:italic> = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (<jats:italic>P<\/jats:italic> = 0.000; odds ratio, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 25.5; 95% confidence interval, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 11.7\u201355.5), any previous affective disorder (<jats:italic>P<\/jats:italic> = 0.000; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 26.0; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 10.5\u201364.0), or specifically a personality disorder (<jats:italic>P<\/jats:italic> = 0.028; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3.8; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.2\u201312.7) increased the risk of <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>. No woman in either group committed suicide during the first year after childbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Whereas mothers who receive <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> treatment are not at increased risk of <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>, the risk is increased among mothers with a history of mental illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13788","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T07:03:27Z","timestamp":1449990207000},"page":"435-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk of postnatal depression or suicide after in vitro 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