{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:08:44Z","timestamp":1789528124374,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Observational studies showed that women with a donor oocyte (<jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content>) pregnancy have an increased risk of pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Systematic review and meta\u2010analysis to compare pregnancy complications of <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content> pregnancy with autologous oocyte <jats:italic>in vitro<\/jats:italic> fertilisation (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>), and whether <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content> pregnancy acts as an independent risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Online searches of databases from 1 January 1980 to 31 January 2015 were performed using a set of relevant keywords.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>All studies comparing pregnancy complications of women with donor oocyte <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> and autologous oocyte <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Data collected included demographics and pregnancy complications. Methodological quality assessment was performed using the Newcastle\u2013Ottawa scale. Statistical analysis was performed using <jats:sc>review manager<\/jats:sc> 5.3 and <jats:sc>stata<\/jats:sc> 13.0. Meta\u2010regression was performed for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>In total, 11 studies (<jats:italic>n<\/jats:italic> = 81 752) were included. Ten studies (<jats:italic>n<\/jats:italic> = 11 539) examined the primary outcome. The risk of developing hypertensive disorders in pregnancy was significantly higher for <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content> pregnancy (odds ratio, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.92; 95% confidence interval, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.21\u20134.78). Further subgroup analysis for singleton and twin pregnancies showed that the risk was significantly higher for <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content> pregnancy in each group. Secondary outcomes including small for gestational age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.81), caesarean section (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.71), and preterm delivery (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.34) were significantly higher with <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content> pregnancy. Meta\u2010regression for the covariate of age suggested that risk was independent of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Author's conclusions<\/jats:title><jats:p>Donor oocyte pregnancy acts as an independent risk factor for pregnancy complications, including hypertensive disorders, small for gestational age, and preterm delivery. Women should be counselled carefully before undergoing <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content>\u2010assisted conception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Donor oocyte conception is an independent risk factor for obstetric complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13910","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T08:25:08Z","timestamp":1454919908000},"page":"1471-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Donor oocyte conception and pregnancy complications: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"123","author":[{"given":"YB","family":"Jeve","sequence":"first","affiliation":[{"name":"University Hospitals of Leicester NHS Trust Leicester UK"},{"name":"Leicester Fertility Centre University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Potdar","sequence":"additional","affiliation":[{"name":"Leicester Fertility Centre University Hospitals of Leicester NHS Trust Leicester UK"},{"name":"University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Opoku","sequence":"additional","affiliation":[{"name":"Homerton University Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Khare","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500060045020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu175"},{"key":"e_1_2_6_4_1","first-page":"181","article-title":"Oocyte donation treats infertility in survivors of malignancies: ten\u2010year experience","volume":"18","author":"Kavic SM","year":"2001","journal-title":"J Assist Reprod Genet"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.02.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02335-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000240139.46018.bd"},{"key":"e_1_2_6_8_1","unstructured":"HFEA.Fertility treatment in 2013: trends and figures. Human Fertilisation and Embryology authority United Kingdom 2014."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92762-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90693-D"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10096.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019508"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2636"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.059"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_6_16_1","first-page":"O\u2010094","volume-title":"Obstetric Outcomes after Oocyte Donation in Patients With Premature Ovarian Failure","author":"Kim HSYK","year":"2005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138541"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.044"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32112-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_23_1","unstructured":"HigginsJPT AltmanDG G\u00f8tzschePC J\u00fcniP MoherD OxmanAD et al.The Cochrane Collaboration's tool for assessing risk of bias in randomised trials2011 2011\u201010\u201018 10:55:48."},{"key":"e_1_2_6_24_1","unstructured":"Cochrane. Review Manager. 5.3 ed.Copenhagen:The Nordic Cochrane Centre Copenhagen 2014."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.128"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.01.055"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-42"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.808"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-42"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.059"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.08.105"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fb8e59"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.777422"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.029"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61261-7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.162"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.709"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der469"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.717"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq017"},{"key":"e_1_2_6_41_1","first-page":"23","article-title":"Oocyte donation: a risk factor for pregnancy\u2010induced hypertension \u2013 A meta\u2010analysis and case series [German;English] Eizellspende \u2013 Ein risikofaktor fur schwangerschaftshochdruck metaanalyse und fallserie","volume":"108","author":"Pecks U","year":"2011","journal-title":"Deutsches Arzteblatt"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.706"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.13"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq007"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00006.2013"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.01.008"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.06.004"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.06.004"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.144"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010122"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1285101"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq080"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00974-9"},{"key":"e_1_2_6_54_1","first-page":"Cd010047","article-title":"Vitrification versus slow freezing for women undergoing oocyte cryopreservation","volume":"9","author":"Glujovsky D","year":"2014","journal-title":"Cochrane Database Syst Rev (Online)"}],"container-title":["BJOG: An International Journal of Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1471-0528.13910","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.13910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:27:19Z","timestamp":1696357639000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/1471-0528.13910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/1471-0528.13910"],"URL":"https:\/\/doi.org\/10.1111\/1471-0528.13910","archive":["Portico"],"relation":{},"ISSN":["1470-0328","1471-0528"],"issn-type":[{"value":"1470-0328","type":"print"},{"value":"1471-0528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]},"assertion":[{"value":"2015-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}