{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:06:00Z","timestamp":1787065560107,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the incidence and occupational variation of granulosa cell tumours (\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      s) in Finland, Iceland, Norway and Sweden over a 60\u2010year period, 1953\u20132012.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A longitudinal cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and population<\/jats:title>\n                    <jats:p>\n                      Finland, Iceland, Norway and Sweden and a total of 249 million women over a 60\u2010year period (1953\u20132012). The\n                      <jats:styled-content style=\"fixed-case\">NOCCA<\/jats:styled-content>\n                      (Nordic Occupational Cancer Study) included 6.4 million women with 776 incident\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      cases diagnosed until the end of follow up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Incidence rates were calculated from the national cancer registries and compared using quasi\u2010Poisson regression models. Occupation\u2010specific standardised incidence ratios (\n                      <jats:styled-content style=\"fixed-case\">SIR<\/jats:styled-content>\n                      s) were calculated from the Nordic Occupational Cancer (\n                      <jats:styled-content style=\"fixed-case\">NOCCA<\/jats:styled-content>\n                      ) database.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Incidence rates and standardised incidence ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The age\u2010adjusted (World Standard) incidence rates remained quite constant: about 0.6\u20130.8 per 100\u00a0000 for most of the study period. The age\u2010specific incidence was highest at 50\u201364\u00a0years of age. There were no occupations with significantly increased risk of\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      . Major changes in the use of oral contraceptives, postmenopausal hormonal therapy, fertility rate and lifestyle in general during the study period and among different occupational categories do not appear to have a marked effect on the incidence of\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings support the concept of\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      as a primarily sporadic, not exposure\u2010related, cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Tweetable abstract<\/jats:title>\n                    <jats:p>\n                      The Nordic incidence rates of\n                      <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                      s show stability over time and among different occupational categories.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1471-0528.13949","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T01:10:56Z","timestamp":1456708256000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Incidence and occupational variation of ovarian granulosa cell tumours in Finland, Iceland, Norway and Sweden during 1953\u20132012: a longitudinal cohort study"],"prefix":"10.1111","volume":"124","author":[{"given":"S","family":"Bryk","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Pukkala","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland"},{"name":"School of Health Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010I","family":"Martinsen","sequence":"additional","affiliation":[{"name":"Department of Research Cancer Registry of Norway Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Unkila\u2010Kallio","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Tryggvadottir","sequence":"additional","affiliation":[{"name":"Icelandic Cancer Registry Reykjavik 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