{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:03:24Z","timestamp":1767827004707,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["EC07\/90023"],"award-info":[{"award-number":["EC07\/90023"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether maintenance treatment with vaginal progesterone after an arrested preterm labour reduces the incidence of preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicentre, randomised, double\u2010blind, placebo\u2010controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Twelve tertiary care centres in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 265 women with singleton pregnancy, preterm labour successfully arrested with tocolytic treatment, and cervical length of &lt;25\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomisation was stratified by gestational age (from 24.0 to &lt;31.0\u00a0weeks of gestation and from 31.0 to &lt;34.0\u00a0weeks of gestation) and centre. Patients were randomly assigned, in a 1\u00a0:\u00a01 ratio, to either daily vaginal capsules of 200\u00a0mg progesterone or placebo until delivery or 36.6\u00a0weeks of gestation, whichever occurred first.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Primary outcome was delivery before 34.0 and 37.0\u00a0weeks of gestation. Secondary outcomes were discharge\u2010to\u2010delivery time, readmissions because of preterm labour, emergency service use, and neonatal morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From June 2008 through June 2012, 1419 women were screened: 472 met the inclusion criteria and 265 were randomised. The final analysis included 258 women: 126 in the progesterone group and 132 in the placebo group. There were no significant differences between the progesterone and placebo groups in terms of delivery at &lt;34\u00a0weeks of gestation [9\/126 (7.1%) versus 10\/132 (7.6%), <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.91] or &lt;37\u00a0weeks of gestation [36\/126 (28.6%) versus 29\/132 (22.0%), <jats:italic>P\u00a0<\/jats:italic>=\u00a00.22]. There were no differences observed between groups when considering the two strata of gestational age at inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A maintenance treatment of 200\u00a0mg of daily vaginal progesterone capsules in women discharged home after an episode of arrested preterm labour did not significantly reduce the rate of preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Maintenance progesterone in 258 women after arrested <jats:styled-content style=\"fixed-case\">PTL<\/jats:styled-content> showed no benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13956","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:28:23Z","timestamp":1459459703000},"page":"1990-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Vaginal progesterone as maintenance treatment after an episode of preterm labour (<scp>PROMISE<\/scp>) study: a multicentre, double\u2010blind, randomised, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"123","author":[{"given":"M","family":"Palacio","sequence":"first","affiliation":[{"name":"BCNatal Hospital Cl\u00ednic of Barcelona and Hospital Sant Joan de D\u00e9u Fetal i+D Fetal Medicine Research Centre IDIBAPS University of Barcelona Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Cobo","sequence":"additional","affiliation":[{"name":"BCNatal Hospital Cl\u00ednic of Barcelona and Hospital Sant Joan de D\u00e9u Fetal i+D Fetal Medicine Research Centre IDIBAPS University of Barcelona Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Antol\u00edn","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario Universitario lnsular Materno Infantil Las Palmas de Gran Canaria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Mozo de Rosales","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Basurto Bilbao Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JL","family":"Bartha","sequence":"additional","affiliation":[{"name":"Hospital Puerta del Mar C\u00e1diz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Juan","sequence":"additional","affiliation":[{"name":"Hospital de Son Ll\u00e0tzer Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Althaia Xarxa Assistencial Universit\u00e0ria de Manresa Hospital de Sant Joan de D\u00e9u Manresa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Oros","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario Lozano Blesa Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n Red SAMID, RETICS Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c0","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital de Sabadell, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed Sabadell Spain"},{"name":"Institut Universitari Parc Taul\u00ed \u2013 UAB. 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