{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:28:08Z","timestamp":1793035688030,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["171102012"],"award-info":[{"award-number":["171102012"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJOG"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the economic consequences of immediate delivery compared with expectant monitoring in women with preterm non\u2010severe hypertensive disorders of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cost\u2010effectiveness analysis alongside a randomised controlled trial (<jats:styled-content style=\"fixed-case\">HYPITAT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Obstetric departments of seven academic hospitals and 44 non\u2010academic hospitals in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Women diagnosed with non\u2010severe hypertensive disorders of pregnancy between 34<jats:sup>0\/7<\/jats:sup>and 37<jats:sup>0\/7<\/jats:sup>\u00a0weeks of gestation, randomly allocated to either immediate delivery or expectant monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A trial\u2010based cost\u2010effectiveness analysis was performed from a healthcare perspective until final maternal and neonatal discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Health outcomes were expressed as the prevalence of respiratory distress syndrome, defined as the need for supplemental oxygen for &gt;24\u00a0hours combined with radiographic findings typical for respiratory distress syndrome. Costs were estimated from a healthcare perspective until maternal and neonatal discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average costs of immediate delivery (<jats:italic>n<\/jats:italic>\u00a0=\u00a0352) were \u20ac10\u00a0245 versus \u20ac9563 for expectant monitoring (<jats:italic>n<\/jats:italic>\u00a0=\u00a0351), with an average difference of \u20ac682 (95% confidence interval, 95%\u00a0<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2212\u20ac618 to \u20ac2126). This 7% difference predominantly originated from the neonatal admissions, which were \u20ac5672 in the immediate delivery arm and \u20ac3929 in the expectant monitoring arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In women with mild hypertensive disorders between 34<jats:sup>0\/7<\/jats:sup>and 37<jats:sup>0\/7<\/jats:sup>\u00a0weeks of gestation, immediate delivery is more costly than expectant monitoring as a result of differences in neonatal admissions. These findings support expectant monitoring, as the clinical outcomes of the trial demonstrated that expectant monitoring reduced respiratory distress syndrome for a slightly increased risk of maternal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Tweetable abstract<\/jats:title><jats:p>Expectant management in preterm hypertensive disorders is less costly compared with immediate delivery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1471-0528.13957","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:17:49Z","timestamp":1457767069000},"page":"453-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An economic analysis of immediate delivery and expectant monitoring in women with hypertensive disorders of pregnancy, between 34 and 37\u00a0weeks of gestation (<scp>HYPITAT<\/scp>\u2010<scp>II<\/scp>)"],"prefix":"10.1111","volume":"124","author":[{"given":"G\u2010J","family":"van Baaren","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Broekhuijsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Medical Centre Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MG","family":"van Pampus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Onze Lieve Vrouwe Gasthuis Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Ganzevoort","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Sikkema","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology ZGT Almelo Almelo the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MD","family":"Woiski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Oudijk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KWM","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Wilhelmina Children's Hospital Birth Centre Division Woman and Baby University Medical 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